| Game Results |
| Teams | Date | Score |
| Cleveland at Pittsburgh | 9/26/1959 | PIN 14-7 |
| New York at Los Angeles | 9/26/1959 | NYN 16-14 |
| Chicago Bears at Green Bay | 9/27/1959 | CHN 20-14 |
| Detroit at Baltimore | 9/27/1959 | DEN 23-21 |
| Philadelphia at San Francisco | 9/27/1959 | SFN 14-10 |
| Washington at Chicago Cardinals | 9/27/1959 | WAN 24-17 |
| Chicago Bears at Baltimore | 10/3/1959 | BAN 20-0 |
| Cleveland at Chicago Cardinals | 10/4/1959 | CLN 38-14 |
| Detroit at Green Bay | 10/4/1959 | GBN 28-7 |
| New York at Philadelphia | 10/4/1959 | NYN 37-14 |
| Los Angeles at San Francisco | 10/4/1959 | SFN 35-28 |
| Washington at Pittsburgh | 10/4/1959 | PIN 33-31 |
| Baltimore at Detroit | 10/11/1959 | BAN 21-20 |
| Chicago Cardinals at Washington | 10/11/1959 | WAN 21-0 |
| New York at Cleveland | 10/11/1959 | NYN 30-0 |
| Pittsburgh at Philadelphia | 10/11/1959 | PIN 35-35 |
| Los Angeles at Chicago Bears | 10/11/1959 | LAN 23-13 |
| San Francisco at Green Bay | 10/11/1959 | GBN 17-14 |
| Baltimore at Chicago Bears | 10/18/1959 | BAN 35-19 |
| Chicago Cardinals at Cleveland | 10/18/1959 | CCN 34-21 |
| Philadelphia at New York | 10/18/1959 | NYN 21-7 |
| Pittsburgh at Washington | 10/18/1959 | WAN 28-21 |
| Los Angeles at Green Bay | 10/18/1959 | GBN 13-3 |
| San Francisco at Detroit | 10/18/1959 | SFN 21-17 |
| Chicago Bears at San Francisco | 10/25/1959 | CHN 30-17 |
| Detroit at Los Angeles | 10/25/1959 | DEN 16-9 |
| Green Bay at Baltimore | 10/25/1959 | BAN 24-6 |
| New York at Pittsburgh | 10/25/1959 | NYN 17-0 |
| Philadelphia at Chicago Cardinals | 10/25/1959 | CCN 31-14 |
| Washington at Cleveland | 10/25/1959 | CLN 46-13 |
| Chicago Bears at Los Angeles | 11/1/1959 | CHN 16-13 |
| Cleveland at Baltimore | 11/1/1959 | CLN 14-3 |
| Detroit at San Francisco | 11/1/1959 | DEN 30-21 |
| Green Bay at New York | 11/1/1959 | NYN 20-6 |
| Pittsburgh at Chicago Cardinals | 11/1/1959 | CCN 17-16 |
| Washington at Philadelphia | 11/1/1959 | PHN 35-20 |
| Baltimore at Washington | 11/8/1959 | WAN 17-7 |
| Chicago Cardinals at New York | 11/8/1959 | NYN 38-3 |
| Detroit at Pittsburgh | 11/8/1959 | DEN 17-3 |
| Green Bay at Chicago Bears | 11/8/1959 | CHN 23-13 |
| Philadelphia at Cleveland | 11/8/1959 | CLN 21-17 |
| San Francisco at Los Angeles | 11/8/1959 | SFN 31-14 |
| Baltimore at Green Bay | 11/15/1959 | GBN 34-14 |
| Chicago Cardinals at Philadelphia | 11/15/1959 | PHN 17-7 |
| Cleveland at Washington | 11/15/1959 | CLN 23-3 |
| Pittsburgh at New York | 11/15/1959 | PIN 17-16 |
| Los Angeles at Detroit | 11/15/1959 | DEN 24-20 |
| San Francisco at Chicago Bears | 11/15/1959 | CHN 24-3 |
| Chicago Bears at Detroit | 11/22/1959 | CHN 20-10 |
| New York at Chicago Cardinals | 11/22/1959 | NYN 23-9 |
| Pittsburgh at Cleveland | 11/22/1959 | PIN 31-28 |
| Los Angeles at Philadelphia | 11/22/1959 | LAN 21-17 |
| San Francisco at Baltimore | 11/22/1959 | BAN 34-17 |
| Washington at Green Bay | 11/22/1959 | GBN 21-10 |
| Green Bay at Detroit | 11/26/1959 | DEN 36-3 |
| Chicago Bears at Chicago Cardinals | 11/29/1959 | CHN 33-10 |
| Philadelphia at Pittsburgh | 11/29/1959 | PHN 27-27 |
| Los Angeles at Baltimore | 11/29/1959 | BAN 14-13 |
| San Francisco at Cleveland | 11/29/1959 | CLN 31-16 |
| Washington at New York | 11/29/1959 | NYN 23-14 |
| Baltimore at San Francisco | 12/5/1959 | BAN 26-14 |
| Chicago Cardinals at Detroit | 12/6/1959 | CCN 20-20 |
| Cleveland at New York | 12/6/1959 | NYN 27-24 |
| Green Bay at Los Angeles | 12/6/1959 | LAN 21-17 |
| Philadelphia at Washington | 12/6/1959 | WAN 24-22 |
| Pittsburgh at Chicago Bears | 12/6/1959 | CHN 30-17 |
| Baltimore at Los Angeles | 12/12/1959 | BAN 13-10 |
| Chicago Cardinals at Pittsburgh | 12/13/1959 | PIN 36-24 |
| Cleveland at Philadelphia | 12/13/1959 | CLN 33-27 |
| Detroit at Chicago Bears | 12/13/1959 | CHN 34-0 |
| Green Bay at San Francisco | 12/13/1959 | GBN 30-24 |
| New York at Washington | 12/13/1959 | NYN 27-13 |