| League Record Book | |||||
| Passing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Completions | Milt Plum - Cleveland | Chicago Cardinals | 10/4/1959 | Cleveland 38-14 | 27 |
| Most Passing Yards | Norm Van Brocklin - Philadelphia | Cleveland | 12/13/1959 | Cleveland 33-27 | 332 |
| Best Avg Yards Per Pass | Ed Brown - Chicago Bears | Green Bay | 11/8/1959 | Chicago Bears 23-13 | 11.1 |
| Longest Completion | Ed Brown - Chicago Bears | Green Bay | 11/8/1959 | Chicago Bears 23-13 | 83 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Completions | Cleveland | Chicago Cardinals | 10/4/1959 | Cleveland 38-14 | 27 |
| Most Passing Yards | Philadelphia | Cleveland | 12/13/1959 | Cleveland 33-27 | 332 |
| Best Avg Yards Per Pass | Chicago Cardinals | Cleveland | 10/18/1959 | Chicago Cardinals 34-21 | 12.5 |
| Longest Completion | Chicago Bears | Green Bay | 11/8/1959 | Chicago Bears 23-13 | 83 |
| Rushing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Carries | Jim Brown - Cleveland | San Francisco | 11/29/1959 | Cleveland 31-16 | 33 |
| Most Rushing Yards | Jim Brown - Cleveland | San Francisco | 11/29/1959 | Cleveland 31-16 | 274 |
| Best Rushing Avg | Jim Brown - Cleveland | Washington | 10/25/1959 | Cleveland 46-13 | 10.1 |
| Longest Carry | John David Crow - Chicago Cardinals | Washington | 9/27/1959 | Washington 24-17 | 73 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Carries | Green Bay | San Francisco | 12/13/1959 | Green Bay 30-24 | 50 |
| Most Rushing Yards | Cleveland | San Francisco | 11/29/1959 | Cleveland 31-16 | 329 |
| Best Rushing Avg | Cleveland | Philadelphia | 12/13/1959 | Cleveland 33-27 | 8.1 |
| Longest Carry | Chicago Cardinals | Washington | 9/27/1959 | Washington 24-17 | 73 |
| Receiving Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Receptions | George Scott - New York | Chicago Cardinals | 11/8/1959 | New York 38-3 | 11 |
| Most Receiving Yards | Tom Tracy - Pittsburgh | Washington | 10/4/1959 | Pittsburgh 33-31 | 144 |
| Best Reception Yardage Avg | Bobby Walston - Philadelphia | Cleveland | 12/13/1959 | Cleveland 33-27 | 27.8 |
| Longest Reception | Harlon Hill - Chicago Bears | Green Bay | 11/8/1959 | Chicago Bears 23-13 | 83 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Receptions | Cleveland | Chicago Cardinals | 10/4/1959 | Cleveland 38-14 | 27 |
| Most Receiving Yards | Philadelphia | Cleveland | 12/13/1959 | Cleveland 33-27 | 332 |
| Best Reception Yardage Avg | Washington | Philadelphia | 12/6/1959 | Washington 24-22 | 22.4 |
| Longest Reception | Chicago Bears | Green Bay | 11/8/1959 | Chicago Bears 23-13 | 83 |
| Kickoff Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Dick James - Washington | New York | 12/13/1959 | New York 27-13 | 6 |
| Best Return Yardage Avg | Abe Woodson - San Francisco | Los Angeles | 10/4/1959 | San Francisco 35-28 | 61.5 |
| Longest Return | Abe Woodson - San Francisco | Los Angeles | 10/4/1959 | San Francisco 35-28 | 97 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Philadelphia | New York | 10/4/1959 | New York 37-14 | 7 |
| Best Return Yardage Avg | Los Angeles | Green Bay | 12/6/1959 | Los Angeles 21-17 | 48.7 |
| Longest Return | San Francisco | Los Angeles | 10/4/1959 | San Francisco 35-28 | 97 |
| Punt Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Bill Butler - Green Bay | Detroit | 10/4/1959 | Green Bay 28-7 | 5 |
| Best Return Yardage Avg | Tommy McDonald - Philadelphia | Washington | 11/1/1959 | Philadelphia 35-20 | 95.0 |
| Longest Return | Tommy McDonald - Philadelphia | Washington | 11/1/1959 | Philadelphia 35-20 | 95 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | New York | Los Angeles | 9/26/1959 | New York 16-14 | 5 |
| Best Return Yardage Avg | Philadelphia | Washington | 11/1/1959 | Philadelphia 35-20 | 95.0 |
| Longest Return | Philadelphia | Washington | 11/1/1959 | Philadelphia 35-20 | 95 |
| Defense Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Tackles | Vince Costello - Cleveland | Chicago Cardinals | 10/4/1959 | Cleveland 38-14 | 15 |
| Sacks | Frank Fuller - Chicago Cardinals | New York | 11/22/1959 | New York 23-9 | 4 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Tackles | San Francisco | Baltimore | 12/5/1959 | Baltimore 26-14 | 65 |
| Sacks | Chicago Cardinals | New York | 11/22/1959 | New York 23-9 | 8 |
| Interception Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Interceptions | Jimmy Patton - New York | Philadelphia | 10/18/1959 | New York 21-7 | 3 |
| Best Interception Yardage Avg | Carl Brettschneider - Chicago Cardinals | Philadelphia | 10/25/1959 | Chicago Cardinals 31-14 | 87.0 |
| Longest Interception | Carl Brettschneider - Chicago Cardinals | Philadelphia | 10/25/1959 | Chicago Cardinals 31-14 | 87 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Interceptions | Baltimore | San Francisco | 11/22/1959 | Baltimore 34-17 | 7 |
| Best Interception Yardage Avg | Chicago Cardinals | Philadelphia | 11/15/1959 | Philadelphia 17-7 | 87.0 |
| Longest Interception | Chicago Cardinals | Philadelphia | 10/25/1959 | Chicago Cardinals 31-14 | 87 |