| Game Results |
| Teams | Date | Score |
| New York AFL at Boston | 9/9/1961 | BOA 23-0 |
| Oakland at Houston | 9/9/1961 | OAA 45-45 |
| Denver at Buffalo | 9/10/1961 | DEA 27-14 |
| San Diego at Dallas AFL | 9/10/1961 | DAA 27-24 |
| Denver at Boston | 9/16/1961 | DEA 26-21 |
| St. Louis at New York NFL | 9/17/1961 | NYN 31-16 |
| Los Angeles at Baltimore | 9/17/1961 | BAN 28-7 |
| Pittsburgh at Dallas NFL | 9/17/1961 | PIN 38-14 |
| Detroit at Green Bay | 9/17/1961 | GBN 30-28 |
| Cleveland at Philadelphia | 9/17/1961 | CLN 31-24 |
| Oakland at San Diego | 9/17/1961 | SDA 17-14 |
| New York AFL at Buffalo | 9/17/1961 | NYA 31-10 |
| Washington at San Francisco | 9/17/1961 | SFN 17-7 |
| Chicago at Minnesota | 9/17/1961 | CHN 27-7 |
| Boston at Buffalo | 9/23/1961 | BOA 33-17 |
| Chicago at Los Angeles | 9/23/1961 | LAN 7-6 |
| Detroit at Baltimore | 9/24/1961 | BAN 29-17 |
| Minnesota at Dallas NFL | 9/24/1961 | MNN 44-7 |
| New York NFL at Pittsburgh | 9/24/1961 | NYN 16-3 |
| San Francisco at Green Bay | 9/24/1961 | GBN 16-10 |
| Washington at Philadelphia | 9/24/1961 | WAN 13-7 |
| St. Louis at Cleveland | 9/24/1961 | SLN 17-10 |
| Denver at New York AFL | 9/24/1961 | DEA 17-3 |
| Dallas AFL at Oakland | 9/24/1961 | DAA 45-21 |
| Houston at San Diego | 9/24/1961 | HOA 36-3 |
| San Diego at Buffalo | 9/30/1961 | SDA 27-14 |
| Chicago at Green Bay | 10/1/1961 | GBN 34-7 |
| Dallas NFL at Cleveland | 10/1/1961 | CLN 37-21 |
| Minnesota at Baltimore | 10/1/1961 | BAN 26-23 |
| New York NFL at Washington | 10/1/1961 | NYN 35-14 |
| Pittsburgh at Los Angeles | 10/1/1961 | LAN 20-14 |
| San Francisco at Detroit | 10/1/1961 | SFN 24-24 |
| St. Louis at Philadelphia | 10/1/1961 | PHN 20-19 |
| Denver at Oakland | 10/1/1961 | DEA 31-21 |
| Boston at New York AFL | 10/1/1961 | BOA 20-3 |
| Houston at Dallas AFL | 10/1/1961 | HOA 37-10 |
| San Diego at Boston | 10/7/1961 | BOA 17-6 |
| Baltimore at Green Bay | 10/8/1961 | BAN 27-17 |
| Dallas AFL at Denver | 10/8/1961 | DAA 24-17 |
| Chicago at Detroit | 10/8/1961 | CHN 24-19 |
| Dallas NFL at Minnesota | 10/8/1961 | DAN 38-35 |
| New York NFL at St. Louis | 10/8/1961 | NYN 24-7 |
| Pittsburgh at Philadelphia | 10/8/1961 | PHN 27-10 |
| Los Angeles at San Francisco | 10/8/1961 | SFN 25-14 |
| Washington at Cleveland | 10/8/1961 | CLN 30-27 |
| Buffalo at Houston | 10/8/1961 | HOA 61-35 |
| Houston at Boston | 10/13/1961 | HOA 19-17 |
| New York NFL at Dallas NFL | 10/15/1961 | NYN 20-7 |
| Green Bay at Cleveland | 10/15/1961 | GBN 34-28 |
| Baltimore at Chicago | 10/15/1961 | CHN 31-30 |
| San Diego at New York AFL | 10/15/1961 | SDA 41-24 |
| Dallas AFL at Buffalo | 10/15/1961 | BUA 28-26 |
| Oakland at Denver | 10/15/1961 | DEA 21-16 |
| Washington at Pittsburgh | 10/15/1961 | PIN 16-7 |
| San Francisco at Minnesota | 10/15/1961 | MNN 48-21 |
| Los Angeles at Detroit | 10/15/1961 | LAN 9-7 |
| Philadelphia at St. Louis | 10/15/1961 | PHN 28-21 |
| San Francisco at Chicago | 10/22/1961 | CHN 47-10 |
| Philadelphia at Dallas NFL | 10/22/1961 | DAN 24-17 |
| Green Bay at Minnesota | 10/22/1961 | GBN 47-31 |
| Cleveland at Pittsburgh | 10/22/1961 | CLN 26-13 |
| Baltimore at Detroit | 10/22/1961 | BAN 30-27 |
| Buffalo at Boston | 10/22/1961 | BOA 10-3 |
| Dallas AFL at Houston | 10/22/1961 | HOA 35-10 |
| New York AFL at Denver | 10/22/1961 | DEA 34-3 |
| St. Louis at Washington | 10/22/1961 | WAN 35-14 |
| Los Angeles at New York NFL | 10/22/1961 | NYN 38-21 |
| San Diego at Oakland | 10/22/1961 | SDA 34-31 |
| Detroit at Los Angeles | 10/29/1961 | LAN 27-24 |
| Dallas NFL at New York NFL | 10/29/1961 | NYN 31-7 |
| Cleveland at St. Louis | 10/29/1961 | CLN 33-3 |
| San Francisco at Pittsburgh | 10/29/1961 | PIN 34-17 |
| Philadelphia at Washington | 10/29/1961 | PHN 34-7 |
| Chicago at Baltimore | 10/29/1961 | CHN 31-30 |
| Boston at Dallas AFL | 10/29/1961 | BOA 30-28 |
| Denver at San Diego | 10/29/1961 | SDA 38-24 |
| Houston at Buffalo | 10/29/1961 | HOA 45-9 |
| New York AFL at Oakland | 10/29/1961 | NYA 27-24 |
| Minnesota at Green Bay | 10/29/1961 | GBN 33-14 |
| Dallas AFL at Boston | 11/3/1961 | BOA 24-21 |
| Detroit at San Francisco | 11/5/1961 | DEN 31-13 |
| Green Bay at Baltimore | 11/5/1961 | GBN 38-28 |
| Minnesota at Los Angeles | 11/5/1961 | LAN 34-30 |
| Pittsburgh at Cleveland | 11/5/1961 | PIN 38-27 |
| St. Louis at Dallas NFL | 11/5/1961 | SLN 24-21 |
| Washington at New York NFL | 11/5/1961 | NYN 31-14 |
| Oakland at Buffalo | 11/5/1961 | BUA 31-14 |
| Houston at Denver | 11/5/1961 | HOA 37-11 |
| New York AFL at San Diego | 11/5/1961 | SDA 42-16 |
| Chicago at Philadelphia | 11/5/1961 | CHN 20-10 |
| Oakland at New York AFL | 11/11/1961 | OAA 21-20 |
| Cleveland at Washington | 11/12/1961 | WAN 35-23 |
| San Francisco at Los Angeles | 11/12/1961 | SFN 17-13 |
| Philadelphia at New York NFL | 11/12/1961 | NYN 45-26 |
| Green Bay at Chicago | 11/12/1961 | GBN 23-23 |
| Detroit at St. Louis | 11/12/1961 | SLN 21-14 |
| Dallas NFL at Pittsburgh | 11/12/1961 | PIN 48-17 |
| Baltimore at Minnesota | 11/12/1961 | BAN 17-10 |
| Boston at Houston | 11/12/1961 | BOA 27-19 |
| Buffalo at Dallas AFL | 11/12/1961 | DAA 28-21 |
| San Diego at Denver | 11/12/1961 | SDA 30-3 |
| Oakland at Boston | 11/17/1961 | BOA 40-17 |
| Washington at Dallas NFL | 11/19/1961 | WAN 21-14 |
| St. Louis at Baltimore | 11/19/1961 | BAN 24-13 |
| Los Angeles at Green Bay | 11/19/1961 | GBN 24-0 |
| Philadelphia at Cleveland | 11/19/1961 | CLN 33-10 |
| Detroit at Minnesota | 11/19/1961 | DEN 38-21 |
| Chicago at San Francisco | 11/19/1961 | CHN 17-16 |
| Pittsburgh at New York NFL | 11/19/1961 | NYN 28-24 |
| Buffalo at Denver | 11/19/1961 | DEA 24-6 |
| Dallas AFL at San Diego | 11/19/1961 | SDA 30-14 |
| New York AFL at Houston | 11/19/1961 | HOA 38-10 |
| Green Bay at Detroit | 11/23/1961 | GBN 30-13 |
| Buffalo at New York AFL | 11/23/1961 | BUA 10-10 |
| Minnesota at San Francisco | 11/26/1961 | SFN 23-7 |
| Dallas NFL at Philadelphia | 11/26/1961 | PHN 31-14 |
| Baltimore at Washington | 11/26/1961 | WAN 14-13 |
| New York NFL at Cleveland | 11/26/1961 | CLN 34-14 |
| St. Louis at Pittsburgh | 11/26/1961 | SLN 19-13 |
| Denver at Houston | 11/26/1961 | HOA 41-31 |
| Oakland at Dallas AFL | 11/26/1961 | DAA 21-16 |
| Los Angeles at Chicago | 11/26/1961 | CHN 28-24 |
| Dallas AFL at New York AFL | 12/3/1961 | DAA 34-20 |
| Boston at Denver | 12/3/1961 | BOA 27-16 |
| San Diego at Houston | 12/3/1961 | SDA 34-29 |
| Los Angeles at Minnesota | 12/3/1961 | LAN 49-7 |
| Washington at St. Louis | 12/3/1961 | WAN 27-0 |
| San Francisco at Baltimore | 12/3/1961 | SFN 21-13 |
| Philadelphia at Pittsburgh | 12/3/1961 | PIN 10-3 |
| New York NFL at Green Bay | 12/3/1961 | NYN 44-16 |
| Detroit at Chicago | 12/3/1961 | CHN 30-17 |
| Cleveland at Dallas NFL | 12/3/1961 | CLN 30-21 |
| Buffalo at Oakland | 12/3/1961 | OAA 11-0 |
| Boston at Oakland | 12/9/1961 | BOA 42-12 |
| Baltimore at Los Angeles | 12/9/1961 | LAN 31-28 |
| Green Bay at San Francisco | 12/10/1961 | SFN 20-13 |
| Dallas NFL at St. Louis | 12/10/1961 | SLN 21-7 |
| Cleveland at Chicago | 12/10/1961 | CLN 40-35 |
| Buffalo at San Diego | 12/10/1961 | SDA 17-6 |
| Denver at Dallas AFL | 12/10/1961 | DEA 21-7 |
| Houston at New York AFL | 12/10/1961 | HOA 41-7 |
| Pittsburgh at Washington | 12/10/1961 | PIN 27-24 |
| New York NFL at Philadelphia | 12/10/1961 | NYN 38-24 |
| Minnesota at Detroit | 12/10/1961 | MNN 31-21 |
| Baltimore at San Francisco | 12/16/1961 | SFN 14-10 |
| Cleveland at New York NFL | 12/17/1961 | NYN 38-21 |
| Dallas NFL at Washington | 12/17/1961 | WAN 31-14 |
| Green Bay at Los Angeles | 12/17/1961 | GBN 34-14 |
| Minnesota at Chicago | 12/17/1961 | MNN 31-28 |
| Pittsburgh at St. Louis | 12/17/1961 | PIN 34-14 |
| Philadelphia at Detroit | 12/17/1961 | DEN 27-17 |
| Boston at San Diego | 12/17/1961 | SDA 29-3 |
| Houston at Oakland | 12/17/1961 | HOA 52-38 |
| New York AFL at Dallas AFL | 12/17/1961 | DAA 22-21 |