Game Results | ||
| Teams | Date | Score |
| Houston at San Diego | 9/12/1964 | SDA 27-24 |
| Denver at New York AFL | 9/12/1964 | NYA 24-22 |
| St. Louis at Dallas | 9/12/1964 | SLN 27-7 |
| Kansas City at Buffalo | 9/13/1964 | BUA 20-14 |
| Chicago at Green Bay | 9/13/1964 | GBN 35-7 |
| Baltimore at Minnesota | 9/13/1964 | MNN 31-27 |
| Boston at Oakland | 9/13/1964 | BOA 24-6 |
| New York NFL at Philadelphia | 9/13/1964 | NYN 20-20 |
| Los Angeles at Pittsburgh | 9/13/1964 | LAN 17-15 |
| Detroit at San Francisco | 9/13/1964 | SFN 28-23 |
| Cleveland at Washington | 9/13/1964 | WAN 20-13 |
| Oakland at Houston | 9/19/1964 | OAA 31-24 |
| Detroit at Los Angeles | 9/19/1964 | LAN 23-20 |
| Denver at Buffalo | 9/20/1964 | BUA 33-27 |
| St. Louis at Cleveland | 9/20/1964 | CLN 32-27 |
| Washington at Dallas | 9/20/1964 | DAN 27-17 |
| Baltimore at Green Bay | 9/20/1964 | GBN 17-3 |
| Chicago at Minnesota | 9/20/1964 | MNN 21-20 |
| San Francisco at Philadelphia | 9/20/1964 | PHN 27-14 |
| New York NFL at Pittsburgh | 9/20/1964 | NYN 24-22 |
| Boston at San Diego | 9/20/1964 | SDA 21-19 |
| Washington at New York NFL | 9/25/1964 | WAN 34-0 |
| San Diego at Buffalo | 9/26/1964 | SDA 28-19 |
| Chicago at Baltimore | 9/27/1964 | BAN 20-17 |
| New York AFL at Boston | 9/27/1964 | NYA 28-24 |
| Houston at Denver | 9/27/1964 | HOA 34-27 |
| Kansas City at Oakland | 9/27/1964 | OAA 24-21 |
| Minnesota at Los Angeles | 9/27/1964 | LAN 26-3 |
| Cleveland at Philadelphia | 9/27/1964 | CLN 26-20 |
| Dallas at Pittsburgh | 9/27/1964 | PIN 20-3 |
| St. Louis at San Francisco | 9/27/1964 | SLN 27-23 |
| Green Bay at Detroit | 9/28/1964 | DEN 12-10 |
| Oakland at Buffalo | 10/3/1964 | BUA 38-7 |
| San Diego at New York AFL | 10/3/1964 | SDA 23-21 |
| Los Angeles at Baltimore | 10/4/1964 | LAN 30-13 |
| Dallas at Cleveland | 10/4/1964 | DAN 20-10 |
| Boston at Denver | 10/4/1964 | BOA 23-10 |
| New York NFL at Detroit | 10/4/1964 | DEN 14-3 |
| Minnesota at Green Bay | 10/4/1964 | GBN 45-17 |
| Houston at Kansas City | 10/4/1964 | KCA 24-12 |
| Pittsburgh at Philadelphia | 10/4/1964 | PHN 20-16 |
| Chicago at San Francisco | 10/4/1964 | SFN 38-14 |
| St. Louis at Washington | 10/4/1964 | WAN 17-13 |
| San Diego at Boston | 10/9/1964 | BOA 13-0 |
| Oakland at New York AFL | 10/10/1964 | OAA 30-7 |
| Pittsburgh at Cleveland | 10/10/1964 | CLN 25-24 |
| Los Angeles at Chicago | 10/11/1964 | CHN 21-20 |
| New York NFL at Dallas | 10/11/1964 | DAN 19-6 |
| Kansas City at Denver | 10/11/1964 | DEA 24-7 |
| San Francisco at Green Bay | 10/11/1964 | SFN 25-21 |
| Buffalo at Houston | 10/11/1964 | HOA 30-25 |
| Detroit at Minnesota | 10/11/1964 | MNN 20-13 |
| Philadelphia at Washington | 10/11/1964 | WAN 28-16 |
| Baltimore at St. Louis | 10/12/1964 | SLN 41-34 |
| Oakland at Boston | 10/16/1964 | BOA 31-7 |
| Houston at New York AFL | 10/17/1964 | NYA 38-24 |
| Green Bay at Baltimore | 10/18/1964 | GBN 17-0 |
| Detroit at Chicago | 10/18/1964 | CHN 28-7 |
| Cleveland at Dallas | 10/18/1964 | CLN 27-17 |
| Buffalo at Kansas City | 10/18/1964 | BUA 26-21 |
| San Francisco at Los Angeles | 10/18/1964 | SFN 22-16 |
| Pittsburgh at Minnesota | 10/18/1964 | MNN 41-28 |
| Philadelphia at New York NFL | 10/18/1964 | NYN 28-10 |
| Denver at San Diego | 10/18/1964 | SDA 28-3 |
| Washington at St. Louis | 10/18/1964 | SLN 20-7 |
| Kansas City at Boston | 10/23/1964 | KCA 13-10 |
| New York AFL at Buffalo | 10/24/1964 | NYA 20-13 |
| New York NFL at Cleveland | 10/25/1964 | CLN 23-14 |
| Baltimore at Detroit | 10/25/1964 | BAN 44-14 |
| Los Angeles at Green Bay | 10/25/1964 | LAN 20-10 |
| San Diego at Houston | 10/25/1964 | SDA 29-6 |
| Denver at Oakland | 10/25/1964 | OAA 37-27 |
| Philadelphia at Pittsburgh | 10/25/1964 | PIN 31-17 |
| Minnesota at San Francisco | 10/25/1964 | SFN 20-13 |
| Dallas at St. Louis | 10/25/1964 | SLN 29-20 |
| Chicago at Washington | 10/25/1964 | WAN 29-14 |
| Boston at New York AFL | 10/31/1964 | BOA 27-17 |
| San Francisco at Baltimore | 11/1/1964 | BAN 20-14 |
| Houston at Buffalo | 11/1/1964 | BUA 22-20 |
| Dallas at Chicago | 11/1/1964 | CHN 23-20 |
| Los Angeles at Detroit | 11/1/1964 | DEN 30-23 |
| Denver at Kansas City | 11/1/1964 | KCA 19-7 |
| Green Bay at Minnesota | 11/1/1964 | GBN 30-13 |
| St. Louis at New York NFL | 11/1/1964 | SLN 31-27 |
| Washington at Philadelphia | 11/1/1964 | PHN 9-7 |
| Cleveland at Pittsburgh | 11/1/1964 | PIN 38-33 |
| Oakland at San Diego | 11/1/1964 | SDA 38-19 |
| Houston at Boston | 11/6/1964 | HOA 27-24 |
| Pittsburgh at St. Louis | 11/8/1964 | SLN 10-3 |
| Dallas at New York NFL | 11/8/1964 | DAN 21-3 |
| Buffalo at New York AFL | 11/8/1964 | BUA 30-13 |
| San Francisco at Minnesota | 11/8/1964 | MNN 36-10 |
| Philadelphia at Los Angeles | 11/8/1964 | PHN 16-16 |
| Oakland at Kansas City | 11/8/1964 | KCA 37-6 |
| Detroit at Green Bay | 11/8/1964 | DEN 25-17 |
| San Diego at Denver | 11/8/1964 | SDA 7-3 |
| Washington at Cleveland | 11/8/1964 | CLN 13-12 |
| Baltimore at Chicago | 11/8/1964 | BAN 16-6 |
| Minnesota at Baltimore | 11/15/1964 | BAN 38-16 |
| Boston at Buffalo | 11/15/1964 | BUA 20-13 |
| Detroit at Cleveland | 11/15/1964 | CLN 19-10 |
| Philadelphia at Dallas | 11/15/1964 | PHN 23-21 |
| New York AFL at Denver | 11/15/1964 | NYA 45-21 |
| San Diego at Kansas City | 11/15/1964 | KCA 24-17 |
| Chicago at Los Angeles | 11/15/1964 | LAN 19-10 |
| Houston at Oakland | 11/15/1964 | HOA 34-29 |
| Washington at Pittsburgh | 11/15/1964 | WAN 30-17 |
| Green Bay at San Francisco | 11/15/1964 | GBN 31-17 |
| New York NFL at St. Louis | 11/15/1964 | SLN 27-13 |
| Denver at Boston | 11/20/1964 | BOA 16-0 |
| Dallas at Washington | 11/22/1964 | DAN 16-7 |
| St. Louis at Philadelphia | 11/22/1964 | SLN 26-24 |
| New York AFL at Oakland | 11/22/1964 | OAA 13-7 |
| Pittsburgh at New York NFL | 11/22/1964 | PIN 28-3 |
| Baltimore at Los Angeles | 11/22/1964 | LAN 33-17 |
| Kansas City at Houston | 11/22/1964 | KCA 28-10 |
| Cleveland at Green Bay | 11/22/1964 | GBN 21-7 |
| Minnesota at Detroit | 11/22/1964 | MNN 34-27 |
| San Francisco at Chicago | 11/22/1964 | CHN 42-24 |
| Chicago at Detroit | 11/26/1964 | CHN 24-21 |
| Buffalo at San Diego | 11/26/1964 | BUA 41-6 |
| Philadelphia at Cleveland | 11/29/1964 | PHN 27-13 |
| Green Bay at Dallas | 11/29/1964 | GBN 30-21 |
| Oakland at Denver | 11/29/1964 | DEA 38-20 |
| Kansas City at New York AFL | 11/29/1964 | NYA 20-6 |
| Boston at Houston | 11/29/1964 | BOA 20-17 |
| Los Angeles at Minnesota | 11/29/1964 | MNN 17-12 |
| St. Louis at Pittsburgh | 11/29/1964 | PIN 51-27 |
| Baltimore at San Francisco | 11/29/1964 | SFN 14-10 |
| New York NFL at Washington | 11/29/1964 | WAN 13-0 |
| Green Bay at Chicago | 12/5/1964 | CHN 24-21 |
| Pittsburgh at Washington | 12/6/1964 | PIN 33-0 |
| Cleveland at St. Louis | 12/6/1964 | CLN 41-14 |
| Los Angeles at San Francisco | 12/6/1964 | SFN 13-12 |
| New York AFL at San Diego | 12/6/1964 | SDA 30-26 |
| Dallas at Philadelphia | 12/6/1964 | PHN 16-10 |
| Buffalo at Oakland | 12/6/1964 | BUA 44-6 |
| Minnesota at New York NFL | 12/6/1964 | MNN 41-28 |
| Boston at Kansas City | 12/6/1964 | KCA 20-19 |
| Detroit at Baltimore | 12/6/1964 | BAN 37-9 |
| Cleveland at New York NFL | 12/12/1964 | CLN 27-16 |
| Philadelphia at St. Louis | 12/13/1964 | PHN 40-6 |
| Kansas City at San Diego | 12/13/1964 | KCA 31-31 |
| Green Bay at Los Angeles | 12/13/1964 | GBN 24-9 |
| New York AFL at Houston | 12/13/1964 | NYA 31-31 |
| San Francisco at Detroit | 12/13/1964 | DEN 20-10 |
| Buffalo at Denver | 12/13/1964 | BUA 52-18 |
| Pittsburgh at Dallas | 12/13/1964 | PIN 6-6 |
| Minnesota at Chicago | 12/13/1964 | MNN 27-20 |
| Washington at Baltimore | 12/13/1964 | BAN 21-13 |
| Buffalo at Boston | 12/20/1964 | BUA 27-14 |
| Denver at Houston | 12/20/1964 | DEA 33-32 |
| New York AFL at Kansas City | 12/20/1964 | KCA 28-24 |
| San Diego at Oakland | 12/20/1964 | SDA 34-22 |