| Game Results |
| Teams | Date | Score |
| Oakland at Miami | 9/2/1966 | OAA 20-9 |
| Denver at Houston | 9/3/1966 | HOA 20-10 |
| Buffalo at San Diego | 9/4/1966 | BUA 21-16 |
| New York AFL at Miami | 9/9/1966 | NYA 24-7 |
| Baltimore at Green Bay | 9/10/1966 | GBN 38-3 |
| Oakland at Houston | 9/10/1966 | OAA 26-13 |
| Boston at San Diego | 9/10/1966 | SDA 16-5 |
| Los Angeles at Atlanta | 9/11/1966 | LAN 35-3 |
| Chicago at Detroit | 9/11/1966 | CHN 20-16 |
| Philadelphia at St. Louis | 9/11/1966 | SLN 21-7 |
| New York NFL at Pittsburgh | 9/11/1966 | NYN 20-17 |
| Minnesota at San Francisco | 9/11/1966 | SFN 35-31 |
| Cleveland at Washington | 9/11/1966 | CLN 21-7 |
| Kansas City at Buffalo | 9/11/1966 | KCA 20-17 |
| Chicago at Los Angeles | 9/16/1966 | LAN 21-7 |
| Atlanta at Philadelphia | 9/18/1966 | PHN 37-7 |
| Green Bay at Cleveland | 9/18/1966 | GBN 24-17 |
| Detroit at Pittsburgh | 9/18/1966 | PIN 28-16 |
| Baltimore at Minnesota | 9/18/1966 | BAN 31-20 |
| New York NFL at Dallas | 9/18/1966 | DAN 33-3 |
| Washington at St. Louis | 9/18/1966 | SLN 27-14 |
| Kansas City at Oakland | 9/18/1966 | KCA 30-24 |
| Miami at Buffalo | 9/18/1966 | BUA 24-21 |
| Houston at New York AFL | 9/18/1966 | NYA 35-12 |
| Boston at Denver | 9/18/1966 | BOA 17-7 |
| Houston at Buffalo | 9/25/1966 | BUA 17-7 |
| New York AFL at Denver | 9/25/1966 | NYA 13-0 |
| San Diego at Oakland | 9/25/1966 | SDA 34-10 |
| Kansas City at Boston | 9/25/1966 | KCA 31-15 |
| San Francisco at Baltimore | 9/25/1966 | SFN 20-10 |
| Washington at Pittsburgh | 9/25/1966 | WAN 27-7 |
| New York NFL at Philadelphia | 9/25/1966 | NYN 20-20 |
| Minnesota at Dallas | 9/25/1966 | DAN 31-17 |
| Los Angeles at Green Bay | 9/25/1966 | GBN 23-10 |
| St. Louis at Cleveland | 9/25/1966 | CLN 27-14 |
| Atlanta at Detroit | 9/25/1966 | DEN 47-14 |
| San Francisco at Los Angeles | 9/30/1966 | LAN 20-0 |
| Buffalo at Kansas City | 10/2/1966 | BUA 24-10 |
| Miami at San Diego | 10/2/1966 | SDA 24-7 |
| New York AFL at Boston | 10/2/1966 | NYA 21-10 |
| Houston at Denver | 10/2/1966 | HOA 23-22 |
| Pittsburgh at Washington | 10/2/1966 | PIN 34-31 |
| St. Louis at Philadelphia | 10/2/1966 | SLN 28-10 |
| Cleveland at New York NFL | 10/2/1966 | CLN 31-7 |
| Chicago at Minnesota | 10/2/1966 | MNN 23-21 |
| Detroit at Green Bay | 10/2/1966 | GBN 24-0 |
| Dallas at Atlanta | 10/2/1966 | DAN 45-9 |
| San Diego at New York AFL | 10/8/1966 | NYA 17-7 |
| Denver at Kansas City | 10/8/1966 | KCA 30-6 |
| Boston at Buffalo | 10/8/1966 | BUA 20-7 |
| Pittsburgh at Cleveland | 10/8/1966 | CLN 19-10 |
| Atlanta at Washington | 10/9/1966 | WAN 20-11 |
| Baltimore at Chicago | 10/9/1966 | BAN 27-3 |
| Los Angeles at Detroit | 10/9/1966 | LAN 34-14 |
| Green Bay at San Francisco | 10/9/1966 | GBN 16-13 |
| New York NFL at St. Louis | 10/9/1966 | SLN 29-6 |
| Philadelphia at Dallas | 10/9/1966 | DAN 34-10 |
| Miami at Oakland | 10/9/1966 | OAA 22-3 |
| San Francisco at Atlanta | 10/16/1966 | SFN 34-7 |
| Green Bay at Chicago | 10/16/1966 | CHN 17-0 |
| Detroit at Baltimore | 10/16/1966 | BAN 37-23 |
| Los Angeles at Minnesota | 10/16/1966 | MNN 22-21 |
| Philadelphia at Pittsburgh | 10/16/1966 | PHN 31-31 |
| Dallas at St. Louis | 10/16/1966 | DAN 37-15 |
| Washington at New York NFL | 10/16/1966 | NYN 34-27 |
| Denver at Miami | 10/16/1966 | DEA 34-31 |
| Oakland at Kansas City | 10/16/1966 | KCA 43-7 |
| New York AFL at Houston | 10/16/1966 | NYA 28-7 |
| San Diego at Buffalo | 10/16/1966 | SDA 17-14 |
| Atlanta at Green Bay | 10/23/1966 | GBN 3-0 |
| Dallas at Cleveland | 10/23/1966 | DAN 38-14 |
| Detroit at San Francisco | 10/23/1966 | DEN 23-21 |
| Los Angeles at Chicago | 10/23/1966 | LAN 14-12 |
| Minnesota at Baltimore | 10/23/1966 | BAN 16-13 |
| Philadelphia at New York NFL | 10/23/1966 | PHN 49-21 |
| St. Louis at Washington | 10/23/1966 | SLN 30-17 |
| Miami at Houston | 10/23/1966 | HOA 19-14 |
| Oakland at New York AFL | 10/23/1966 | OAA 32-24 |
| Kansas City at Denver | 10/23/1966 | KCA 16-10 |
| San Diego at Boston | 10/23/1966 | BOA 31-28 |
| Houston at Kansas City | 10/30/1966 | KCA 32-30 |
| Denver at San Diego | 10/30/1966 | SDA 21-7 |
| Oakland at Boston | 10/30/1966 | BOA 22-14 |
| Buffalo at New York AFL | 10/30/1966 | NYA 17-14 |
| San Francisco at Minnesota | 10/30/1966 | MNN 26-17 |
| Pittsburgh at Dallas | 10/30/1966 | DAN 41-8 |
| Washington at Philadelphia | 10/30/1966 | WAN 31-31 |
| Baltimore at Los Angeles | 10/30/1966 | BAN 27-24 |
| Green Bay at Detroit | 10/30/1966 | GBN 21-17 |
| Cleveland at Atlanta | 10/30/1966 | CLN 25-9 |
| Chicago at St. Louis | 10/31/1966 | SLN 12-10 |
| Buffalo at Miami | 11/6/1966 | BUA 30-10 |
| Denver at Boston | 11/6/1966 | BOA 19-13 |
| San Diego at Kansas City | 11/6/1966 | SDA 31-13 |
| Houston at Oakland | 11/6/1966 | OAA 30-8 |
| Washington at Baltimore | 11/6/1966 | BAN 28-21 |
| St. Louis at New York NFL | 11/6/1966 | SLN 33-3 |
| Los Angeles at San Francisco | 11/6/1966 | LAN 23-7 |
| Minnesota at Green Bay | 11/6/1966 | GBN 36-0 |
| Dallas at Philadelphia | 11/6/1966 | DAN 24-17 |
| Cleveland at Pittsburgh | 11/6/1966 | CLN 27-7 |
| Detroit at Chicago | 11/6/1966 | DEN 37-21 |
| Baltimore at Atlanta | 11/13/1966 | BAN 28-3 |
| San Francisco at Chicago | 11/13/1966 | SFN 20-17 |
| Detroit at Minnesota | 11/13/1966 | MNN 21-13 |
| New York NFL at Los Angeles | 11/13/1966 | LAN 31-10 |
| Philadelphia at Cleveland | 11/13/1966 | CLN 31-13 |
| St. Louis at Pittsburgh | 11/13/1966 | SLN 32-0 |
| Dallas at Washington | 11/13/1966 | DAN 30-14 |
| Oakland at San Diego | 11/13/1966 | SDA 45-35 |
| Miami at Kansas City | 11/13/1966 | KCA 34-3 |
| Houston at Boston | 11/13/1966 | BOA 34-17 |
| New York AFL at Buffalo | 11/13/1966 | BUA 30-7 |
| Baltimore at Detroit | 11/20/1966 | BAN 27-20 |
| Chicago at Green Bay | 11/20/1966 | GBN 20-16 |
| Minnesota at Los Angeles | 11/20/1966 | LAN 21-17 |
| Atlanta at New York NFL | 11/20/1966 | NYN 33-3 |
| Dallas at Pittsburgh | 11/20/1966 | DAN 23-10 |
| Philadelphia at San Francisco | 11/20/1966 | PHN 20-13 |
| Washington at Cleveland | 11/20/1966 | WAN 27-21 |
| Boston at Kansas City | 11/20/1966 | KCA 20-14 |
| Buffalo at Houston | 11/20/1966 | BUA 13-6 |
| Oakland at Denver | 11/20/1966 | DEA 34-19 |
| Miami at New York AFL | 11/20/1966 | NYA 13-10 |
| Cleveland at Dallas | 11/24/1966 | DAN 21-20 |
| San Francisco at Detroit | 11/24/1966 | SFN 23-13 |
| Buffalo at Oakland | 11/24/1966 | OAA 13-10 |
| Boston at Miami | 11/27/1966 | BOA 26-3 |
| San Diego at Denver | 11/27/1966 | SDA 31-14 |
| Kansas City at New York AFL | 11/27/1966 | KCA 42-7 |
| Pittsburgh at St. Louis | 11/27/1966 | SLN 6-0 |
| New York NFL at Washington | 11/27/1966 | WAN 37-17 |
| Green Bay at Minnesota | 11/27/1966 | MNN 10-6 |
| Los Angeles at Baltimore | 11/27/1966 | LAN 35-7 |
| Atlanta at Chicago | 11/27/1966 | CHN 41-13 |
| New York AFL at Oakland | 12/3/1966 | OAA 17-10 |
| Atlanta at Minnesota | 12/4/1966 | MNN 21-20 |
| New York NFL at Cleveland | 12/4/1966 | CLN 31-14 |
| Pittsburgh at Philadelphia | 12/4/1966 | PHN 24-21 |
| Detroit at Los Angeles | 12/4/1966 | DEN 34-24 |
| Chicago at Baltimore | 12/4/1966 | BAN 20-17 |
| St. Louis at Dallas | 12/4/1966 | SLN 23-20 |
| San Francisco at Green Bay | 12/4/1966 | GBN 19-7 |
| Miami at Denver | 12/4/1966 | MIA 23-14 |
| Buffalo at Boston | 12/4/1966 | BUA 7-6 |
| San Diego at Houston | 12/4/1966 | SDA 31-21 |
| Green Bay at Baltimore | 12/10/1966 | GBN 20-7 |
| Kansas City at Miami | 12/11/1966 | KCA 31-17 |
| Denver at Oakland | 12/11/1966 | OAA 28-13 |
| Boston at Houston | 12/11/1966 | BOA 16-6 |
| New York AFL at San Diego | 12/11/1966 | SDA 28-6 |
| St. Louis at Atlanta | 12/11/1966 | SLN 24-13 |
| Pittsburgh at New York NFL | 12/11/1966 | PIN 23-23 |
| Minnesota at Detroit | 12/11/1966 | MNN 21-16 |
| Washington at Dallas | 12/11/1966 | DAN 28-21 |
| Cleveland at Philadelphia | 12/11/1966 | CLN 17-17 |
| Chicago at San Francisco | 12/11/1966 | SFN 27-20 |
| Cleveland at St. Louis | 12/17/1966 | SLN 13-7 |
| Boston at New York AFL | 12/17/1966 | BOA 23-15 |
| Pittsburgh at Atlanta | 12/18/1966 | PIN 16-10 |
| Green Bay at Los Angeles | 12/18/1966 | LAN 26-9 |
| Minnesota at Chicago | 12/18/1966 | MNN 24-14 |
| Dallas at New York NFL | 12/18/1966 | DAN 20-6 |
| Baltimore at San Francisco | 12/18/1966 | BAN 26-7 |
| Philadelphia at Washington | 12/18/1966 | WAN 22-13 |
| Kansas City at San Diego | 12/18/1966 | KCA 28-24 |
| Denver at Buffalo | 12/18/1966 | BUA 20-0 |
| Houston at Miami | 12/18/1966 | HOA 33-21 |