| Game Results |
| Teams | Date | Score |
| Cincinnati at San Diego | 9/6/1968 | SDA 18-17 |
| Boston at Buffalo | 9/8/1968 | BUA 26-20 |
| Kansas City at Houston | 9/9/1968 | KCA 20-13 |
| Houston at Miami | 9/14/1968 | MIA 16-14 |
| Atlanta at Minnesota | 9/14/1968 | MIN 21-20 |
| Washington at Chicago | 9/15/1968 | WAN 27-17 |
| Detroit at Dallas | 9/15/1968 | DAN 38-0 |
| Cleveland at New Orleans | 9/15/1968 | NON 17-10 |
| Philadelphia at Green Bay | 9/15/1968 | GBN 44-13 |
| New York NFL at Pittsburgh | 9/15/1968 | NYN 27-10 |
| San Francisco at Baltimore | 9/15/1968 | BAN 27-3 |
| New York AFL at Kansas City | 9/15/1968 | KCA 29-3 |
| Oakland at Buffalo | 9/15/1968 | OAA 30-20 |
| Denver at Cincinnati | 9/15/1968 | CIA 27-21 |
| Los Angeles at St. Louis | 9/16/1968 | LAN 20-9 |
| Houston at San Diego | 9/21/1968 | SDA 35-7 |
| Oakland at Miami | 9/21/1968 | MIA 37-11 |
| Buffalo at Cincinnati | 9/22/1968 | CIA 31-14 |
| New York AFL at Boston | 9/22/1968 | NYA 20-13 |
| Baltimore at Atlanta | 9/22/1968 | BAN 27-0 |
| Chicago at Detroit | 9/22/1968 | CHN 37-13 |
| Cleveland at Dallas | 9/22/1968 | DAN 28-17 |
| Minnesota at Green Bay | 9/22/1968 | GBN 25-16 |
| New York NFL at Philadelphia | 9/22/1968 | PHN 33-27 |
| Pittsburgh at Los Angeles | 9/22/1968 | LAN 34-3 |
| St. Louis at San Francisco | 9/22/1968 | SFN 34-20 |
| Washington at New Orleans | 9/22/1968 | NON 17-14 |
| Denver at Kansas City | 9/22/1968 | KCA 41-7 |
| Kansas City at Miami | 9/28/1968 | KCA 24-9 |
| Atlanta at San Francisco | 9/29/1968 | SFN 28-24 |
| Los Angeles at Cleveland | 9/29/1968 | LAN 10-10 |
| Detroit at Green Bay | 9/29/1968 | DEN 20-19 |
| Chicago at Minnesota | 9/29/1968 | MIN 24-10 |
| St. Louis at New Orleans | 9/29/1968 | NON 20-13 |
| Dallas at Philadelphia | 9/29/1968 | DAN 55-14 |
| Baltimore at Pittsburgh | 9/29/1968 | BAN 42-13 |
| Washington at New York NFL | 9/29/1968 | NYN 38-17 |
| Boston at Denver | 9/29/1968 | BOA 26-10 |
| Oakland at Houston | 9/29/1968 | OAA 31-17 |
| San Diego at Cincinnati | 9/29/1968 | CIA 30-18 |
| New York AFL at Buffalo | 9/29/1968 | NYA 35-24 |
| Kansas City at Buffalo | 10/5/1968 | KCA 34-10 |
| San Diego at New York AFL | 10/5/1968 | NYA 41-24 |
| Pittsburgh at Cleveland | 10/5/1968 | CLN 30-13 |
| Boston at Oakland | 10/6/1968 | OAA 40-3 |
| Miami at Houston | 10/6/1968 | MIA 20-17 |
| Cincinnati at Denver | 10/6/1968 | CIA 31-30 |
| San Francisco at Los Angeles | 10/6/1968 | LAN 24-17 |
| Dallas at St. Louis | 10/6/1968 | DAN 34-24 |
| Philadelphia at Washington | 10/6/1968 | WAN 31-6 |
| New Orleans at New York NFL | 10/6/1968 | NON 12-7 |
| Minnesota at Detroit | 10/6/1968 | MIN 9-7 |
| Chicago at Baltimore | 10/6/1968 | BAN 35-7 |
| Green Bay at Atlanta | 10/6/1968 | GBN 24-9 |
| Buffalo at Miami | 10/12/1968 | MIA 24-9 |
| Detroit at Chicago | 10/13/1968 | CHN 10-8 |
| St. Louis at Cleveland | 10/13/1968 | CLN 31-13 |
| Los Angeles at Green Bay | 10/13/1968 | LAN 42-14 |
| Minnesota at New Orleans | 10/13/1968 | NON 24-10 |
| New York NFL at Atlanta | 10/13/1968 | NYN 24-17 |
| Philadelphia at Dallas | 10/13/1968 | DAN 42-21 |
| Pittsburgh at Washington | 10/13/1968 | WAN 30-27 |
| Baltimore at San Francisco | 10/13/1968 | BAN 24-17 |
| San Diego at Oakland | 10/13/1968 | OAA 35-18 |
| Denver at New York AFL | 10/13/1968 | NYA 34-14 |
| Cincinnati at Kansas City | 10/13/1968 | CIA 31-31 |
| Houston at Boston | 10/13/1968 | HOA 17-10 |
| New York AFL at Houston | 10/20/1968 | NYA 16-7 |
| Miami at Cincinnati | 10/20/1968 | CIA 23-13 |
| Atlanta at Los Angeles | 10/20/1968 | LAN 20-0 |
| Cleveland at Baltimore | 10/20/1968 | BAN 27-20 |
| Green Bay at Detroit | 10/20/1968 | DEN 20-10 |
| Dallas at Minnesota | 10/20/1968 | DAN 34-9 |
| San Francisco at New York NFL | 10/20/1968 | NYN 20-7 |
| Chicago at Philadelphia | 10/20/1968 | CHN 52-21 |
| New Orleans at Pittsburgh | 10/20/1968 | NON 31-21 |
| Washington at St. Louis | 10/20/1968 | WAN 20-10 |
| Denver at San Diego | 10/20/1968 | SDA 30-17 |
| Buffalo at Boston | 10/20/1968 | BOA 20-7 |
| Oakland at Kansas City | 10/20/1968 | KCA 33-31 |
| Atlanta at Cleveland | 10/27/1968 | CLN 31-10 |
| San Francisco at Detroit | 10/27/1968 | DEN 16-7 |
| Los Angeles at Baltimore | 10/27/1968 | BAN 14-13 |
| Minnesota at Chicago | 10/27/1968 | MIN 17-10 |
| New Orleans at St. Louis | 10/27/1968 | NON 23-16 |
| Philadelphia at Pittsburgh | 10/27/1968 | PIN 37-29 |
| New York NFL at Washington | 10/27/1968 | NYN 27-17 |
| San Diego at Kansas City | 10/27/1968 | KCA 48-17 |
| Boston at New York AFL | 10/27/1968 | NYA 31-8 |
| Miami at Denver | 10/27/1968 | MIA 27-10 |
| Cincinnati at Oakland | 10/27/1968 | OAA 28-27 |
| Houston at Buffalo | 10/27/1968 | HOA 17-3 |
| Green Bay at Dallas | 10/28/1968 | DAN 10-3 |
| Kansas City at Oakland | 11/3/1968 | KCA 18-17 |
| Houston at Cincinnati | 11/3/1968 | HOA 20-13 |
| Pittsburgh at Atlanta | 11/3/1968 | PIN 26-10 |
| Detroit at Los Angeles | 11/3/1968 | DEN 13-13 |
| Chicago at Green Bay | 11/3/1968 | CHN 30-13 |
| Dallas at New Orleans | 11/3/1968 | NON 26-17 |
| Baltimore at New York NFL | 11/3/1968 | BAN 24-7 |
| St. Louis at Philadelphia | 11/3/1968 | SLN 24-23 |
| Cleveland at San Francisco | 11/3/1968 | CLN 31-14 |
| Washington at Minnesota | 11/3/1968 | WAN 44-23 |
| Miami at San Diego | 11/3/1968 | MIA 13-9 |
| Denver at Boston | 11/3/1968 | BOA 20-10 |
| Buffalo at New York AFL | 11/3/1968 | NYA 17-10 |
| Los Angeles at Atlanta | 11/10/1968 | LAN 40-6 |
| New York NFL at Dallas | 11/10/1968 | DAN 34-24 |
| Baltimore at Detroit | 11/10/1968 | BAN 13-0 |
| Green Bay at Minnesota | 11/10/1968 | MIN 23-21 |
| New Orleans at Cleveland | 11/10/1968 | CLN 44-7 |
| Washington at Philadelphia | 11/10/1968 | PHN 30-17 |
| Pittsburgh at St. Louis | 11/10/1968 | SLN 31-21 |
| San Francisco at Chicago | 11/10/1968 | CHN 23-3 |
| Houston at New York AFL | 11/10/1968 | HOA 14-3 |
| Kansas City at Cincinnati | 11/10/1968 | KCA 20-10 |
| Miami at Buffalo | 11/10/1968 | MIA 31-21 |
| Oakland at Denver | 11/10/1968 | OAA 20-14 |
| San Diego at Boston | 11/10/1968 | BOA 23-20 |
| Boston at Kansas City | 11/17/1968 | BOA 21-20 |
| Cincinnati at Miami | 11/17/1968 | MIA 28-14 |
| Atlanta at Chicago | 11/17/1968 | ATN 37-14 |
| Detroit at Minnesota | 11/17/1968 | DEN 28-14 |
| New Orleans at Green Bay | 11/17/1968 | GBN 21-10 |
| Philadelphia at New York NFL | 11/17/1968 | NYN 36-14 |
| Cleveland at Pittsburgh | 11/17/1968 | CLN 20-10 |
| St. Louis at Baltimore | 11/17/1968 | BAN 27-9 |
| Los Angeles at San Francisco | 11/17/1968 | LAN 24-19 |
| Dallas at Washington | 11/17/1968 | DAN 38-15 |
| San Diego at Buffalo | 11/17/1968 | SDA 22-13 |
| New York AFL at Oakland | 11/17/1968 | NYA 27-13 |
| Denver at Houston | 11/17/1968 | HOA 28-15 |
| Atlanta at St. Louis | 11/24/1968 | ATN 20-20 |
| Dallas at Chicago | 11/24/1968 | DAN 31-14 |
| New Orleans at Detroit | 11/24/1968 | NON 24-7 |
| Minnesota at Baltimore | 11/24/1968 | BAN 20-3 |
| New York NFL at Los Angeles | 11/24/1968 | LAN 31-20 |
| Philadelphia at Cleveland | 11/24/1968 | CLN 35-9 |
| San Francisco at Pittsburgh | 11/24/1968 | PIN 37-24 |
| Green Bay at Washington | 11/24/1968 | GBN 21-3 |
| New York AFL at San Diego | 11/24/1968 | NYA 24-10 |
| Buffalo at Denver | 11/24/1968 | BUA 12-6 |
| Oakland at Cincinnati | 11/24/1968 | OAA 31-7 |
| Miami at Boston | 11/24/1968 | MIA 14-10 |
| Houston at Kansas City | 11/28/1968 | KCA 31-17 |
| Buffalo at Oakland | 11/28/1968 | OAA 37-15 |
| Washington at Dallas | 11/28/1968 | DAN 27-10 |
| Philadelphia at Detroit | 11/28/1968 | PHN 24-21 |
| San Diego at Denver | 12/1/1968 | SDA 20-14 |
| Miami at New York AFL | 12/1/1968 | MIA 10-10 |
| Cincinnati at Boston | 12/1/1968 | CIA 20-20 |
| St. Louis at Pittsburgh | 12/1/1968 | SLN 30-20 |
| New York NFL at Cleveland | 12/1/1968 | NYN 28-17 |
| Chicago at New Orleans | 12/1/1968 | NON 48-7 |
| Los Angeles at Minnesota | 12/1/1968 | LAN 19-16 |
| Green Bay at San Francisco | 12/1/1968 | GBN 37-21 |
| Atlanta at Baltimore | 12/1/1968 | BAN 27-23 |
| Baltimore at Green Bay | 12/7/1968 | BAN 27-3 |
| Buffalo at Houston | 12/7/1968 | BUA 17-9 |
| Kansas City at San Diego | 12/8/1968 | KCA 59-7 |
| Denver at Oakland | 12/8/1968 | OAA 30-8 |
| Cincinnati at New York AFL | 12/8/1968 | CIA 27-7 |
| Boston at Miami | 12/8/1968 | MIA 19-7 |
| Cleveland at Washington | 12/8/1968 | CLN 24-20 |
| Minnesota at San Francisco | 12/8/1968 | MIN 20-17 |
| Pittsburgh at Dallas | 12/8/1968 | DAN 28-14 |
| St. Louis at New York NFL | 12/8/1968 | SLN 41-24 |
| New Orleans at Philadelphia | 12/8/1968 | PHN 34-10 |
| Chicago at Los Angeles | 12/8/1968 | LAN 24-10 |
| Detroit at Atlanta | 12/8/1968 | DEN 26-7 |
| Cleveland at St. Louis | 12/14/1968 | CLN 31-20 |
| Kansas City at Denver | 12/14/1968 | KCA 35-14 |
| Oakland at San Diego | 12/15/1968 | OAA 31-24 |
| New York AFL at Miami | 12/15/1968 | NYA 31-10 |
| Boston at Houston | 12/15/1968 | HOA 23-3 |
| Pittsburgh at New Orleans | 12/15/1968 | PIN 26-19 |
| Minnesota at Philadelphia | 12/15/1968 | MIN 33-13 |
| Dallas at New York NFL | 12/15/1968 | DAN 31-17 |
| Baltimore at Los Angeles | 12/15/1968 | LAN 27-10 |
| Detroit at Washington | 12/15/1968 | DEN 33-31 |
| Green Bay at Chicago | 12/15/1968 | GBN 30-17 |
| San Francisco at Atlanta | 12/15/1968 | SFN 31-17 |