| Game Results |
| Teams | Date | Score |
| Washington at Pittsburgh | 0/0/0 | WAN 36-7 |
| New York AFL at Buffalo | 9/14/1969 | NYA 27-15 |
| Kansas City at San Diego | 9/14/1969 | KCA 26-3 |
| Boston at Denver | 9/14/1969 | DEA 28-20 |
| Miami at Cincinnati | 9/14/1969 | MIA 30-27 |
| Houston at Oakland | 9/14/1969 | HOA 29-17 |
| Miami at Oakland | 9/20/1969 | MIA 38-10 |
| San Diego at Cincinnati | 9/21/1969 | SDA 28-27 |
| Houston at Buffalo | 9/21/1969 | BUA 23-13 |
| New York AFL at Denver | 9/21/1969 | NYA 33-17 |
| Kansas City at Boston | 9/21/1969 | KCA 36-3 |
| San Francisco at Atlanta | 9/21/1969 | ATN 24-23 |
| Los Angeles at Baltimore | 9/21/1969 | LAN 35-35 |
| Chicago at Green Bay | 9/21/1969 | GBN 42-28 |
| Detroit at Pittsburgh | 9/21/1969 | DEN 33-17 |
| St. Louis at Dallas | 9/21/1969 | DAN 21-9 |
| Cleveland at Philadelphia | 9/21/1969 | PHN 27-24 |
| Minnesota at New York NFL | 9/21/1969 | MNN 20-10 |
| Washington at New Orleans | 9/21/1969 | WAN 31-7 |
| Atlanta at Los Angeles | 9/28/1969 | LAN 24-17 |
| Baltimore at Minnesota | 9/28/1969 | BAN 19-19 |
| Chicago at St. Louis | 9/28/1969 | SLN 34-14 |
| Dallas at New Orleans | 9/28/1969 | DAN 24-21 |
| New York NFL at Detroit | 9/28/1969 | DEN 30-0 |
| Pittsburgh at Philadelphia | 9/28/1969 | PHN 31-21 |
| Miami at Houston | 9/28/1969 | MIA 15-13 |
| Kansas City at Cincinnati | 9/28/1969 | KCA 36-3 |
| Oakland at Boston | 9/28/1969 | BOA 21-18 |
| San Francisco at Green Bay | 9/28/1969 | GBN 31-16 |
| Washington at Cleveland | 9/28/1969 | WAN 19-16 |
| New York AFL at San Diego | 9/28/1969 | SDA 48-24 |
| Denver at Buffalo | 9/28/1969 | DEA 30-3 |
| Oakland at Miami | 10/4/1969 | OAA 31-16 |
| Cincinnati at San Diego | 10/4/1969 | SDA 28-10 |
| New York AFL at Boston | 10/5/1969 | NYA 27-14 |
| Kansas City at Denver | 10/5/1969 | KCA 34-20 |
| Buffalo at Houston | 10/5/1969 | BUA 34-30 |
| Washington at San Francisco | 10/5/1969 | WAN 33-14 |
| Baltimore at Atlanta | 10/5/1969 | ATN 17-13 |
| Detroit at Cleveland | 10/5/1969 | DEN 16-0 |
| Green Bay at Minnesota | 10/5/1969 | GBN 24-24 |
| St. Louis at Pittsburgh | 10/5/1969 | SLN 28-26 |
| New Orleans at Los Angeles | 10/5/1969 | NON 26-24 |
| Dallas at Philadelphia | 10/5/1969 | DAN 24-17 |
| Chicago at New York NFL | 10/6/1969 | CHN 31-19 |
| Boston at Buffalo | 10/11/1969 | BUA 23-20 |
| San Diego at Miami | 10/11/1969 | SDA 29-8 |
| Dallas at Atlanta | 10/12/1969 | DAN 24-17 |
| Minnesota at Chicago | 10/12/1969 | CHN 27-9 |
| Green Bay at Detroit | 10/12/1969 | DEN 12-7 |
| Cleveland at New Orleans | 10/12/1969 | CLN 28-27 |
| Philadelphia at Baltimore | 10/12/1969 | BAN 26-14 |
| Oakland at Denver | 10/12/1969 | OAA 24-14 |
| New York AFL at Cincinnati | 10/12/1969 | NYA 34-7 |
| Houston at Kansas City | 10/12/1969 | KCA 22-9 |
| Pittsburgh at New York NFL | 10/12/1969 | NYN 20-10 |
| Los Angeles at San Francisco | 10/12/1969 | LAN 37-26 |
| St. Louis at Washington | 10/12/1969 | SLN 23-20 |
| Pittsburgh at Cleveland | 10/18/1969 | CLN 41-3 |
| San Diego at Boston | 10/19/1969 | BOA 17-15 |
| Miami at Kansas City | 10/19/1969 | KCA 23-0 |
| Denver at Cincinnati | 10/19/1969 | CNA 23-13 |
| Buffalo at Oakland | 10/19/1969 | OAA 17-10 |
| Atlanta at San Francisco | 10/19/1969 | ATN 27-6 |
| Chicago at Detroit | 10/19/1969 | CHN 24-13 |
| Green Bay at Los Angeles | 10/19/1969 | LAN 26-21 |
| Baltimore at New Orleans | 10/19/1969 | BAN 42-33 |
| Minnesota at St. Louis | 10/19/1969 | MNN 34-34 |
| New York NFL at Washington | 10/19/1969 | NYN 17-17 |
| Philadelphia at Dallas | 10/19/1969 | DAN 30-21 |
| Houston at New York AFL | 10/20/1969 | NYA 37-3 |
| Atlanta at Green Bay | 10/26/1969 | ATN 21-21 |
| San Francisco at Baltimore | 10/26/1969 | BAN 41-0 |
| Los Angeles at Chicago | 10/26/1969 | LAN 38-0 |
| St. Louis at Cleveland | 10/26/1969 | CLN 34-10 |
| Detroit at Minnesota | 10/26/1969 | MNN 36-10 |
| Oakland at San Diego | 10/26/1969 | SDA 17-16 |
| Cincinnati at Kansas City | 10/26/1969 | KCA 29-10 |
| Buffalo at Miami | 10/26/1969 | BUA 20-13 |
| New Orleans at Philadelphia | 10/26/1969 | PHN 38-10 |
| Washington at Pittsburgh | 10/26/1969 | WAN 38-17 |
| Boston at New York AFL | 10/26/1969 | NYA 41-17 |
| Denver at Houston | 10/26/1969 | DEA 28-24 |
| New York NFL at Dallas | 10/27/1969 | DAN 38-6 |
| San Diego at Denver | 11/2/1969 | DEA 23-17 |
| Oakland at Cincinnati | 11/2/1969 | OAA 37-17 |
| Miami at New York AFL | 11/2/1969 | NYA 31-7 |
| Houston at Boston | 11/2/1969 | HOA 20-7 |
| Kansas City at Buffalo | 11/2/1969 | KCA 41-3 |
| Washington at Baltimore | 11/2/1969 | BAN 27-26 |
| Los Angeles at Atlanta | 11/2/1969 | LAN 13-6 |
| Chicago at Minnesota | 11/2/1969 | MNN 30-0 |
| Dallas at Cleveland | 11/2/1969 | DAN 24-20 |
| Detroit at San Francisco | 11/2/1969 | DEN 19-7 |
| New Orleans at St. Louis | 11/2/1969 | NON 47-28 |
| Philadelphia at New York NFL | 11/2/1969 | NYN 28-21 |
| Green Bay at Pittsburgh | 11/2/1969 | PIN 17-7 |
| Atlanta at Detroit | 11/9/1969 | ATN 27-27 |
| Cleveland at Minnesota | 11/9/1969 | MNN 38-3 |
| Green Bay at Baltimore | 11/9/1969 | GBN 27-27 |
| New Orleans at Dallas | 11/9/1969 | DAN 38-10 |
| New York NFL at St. Louis | 11/9/1969 | NYN 20-15 |
| Pittsburgh at Chicago | 11/9/1969 | PIN 26-21 |
| San Diego at Kansas City | 11/9/1969 | KCA 23-14 |
| Miami at Boston | 11/9/1969 | BOA 24-16 |
| Denver at Oakland | 11/9/1969 | DEA 23-10 |
| San Francisco at Los Angeles | 11/9/1969 | LAN 23-13 |
| Philadelphia at Washington | 11/9/1969 | WAN 42-14 |
| Buffalo at New York AFL | 11/9/1969 | NYA 44-17 |
| Cincinnati at Houston | 11/9/1969 | HOA 18-17 |
| San Diego at Oakland | 11/16/1969 | SDA 28-17 |
| Miami at Buffalo | 11/16/1969 | BUA 20-10 |
| Kansas City at New York AFL | 11/16/1969 | NYA 23-20 |
| Houston at Denver | 11/16/1969 | HOA 31-7 |
| Boston at Cincinnati | 11/16/1969 | BOA 33-3 |
| Dallas at Washington | 11/16/1969 | DAN 27-24 |
| Baltimore at San Francisco | 11/16/1969 | BAN 31-28 |
| Chicago at Atlanta | 11/16/1969 | ATN 27-7 |
| Minnesota at Green Bay | 11/16/1969 | GBN 24-23 |
| St. Louis at Detroit | 11/16/1969 | SLN 13-10 |
| Cleveland at Pittsburgh | 11/16/1969 | CLN 38-37 |
| New Orleans at New York NFL | 11/16/1969 | NON 30-24 |
| Los Angeles at Philadelphia | 11/16/1969 | LAN 16-6 |
| Atlanta at Washington | 11/23/1969 | ATN 16-14 |
| Baltimore at Chicago | 11/23/1969 | CHN 22-21 |
| Dallas at Los Angeles | 11/23/1969 | DAN 23-13 |
| Detroit at Green Bay | 11/23/1969 | DEN 23-13 |
| New York NFL at Cleveland | 11/23/1969 | CLN 34-24 |
| Pittsburgh at Minnesota | 11/23/1969 | PIN 21-7 |
| Oakland at Kansas City | 11/23/1969 | KCA 37-20 |
| Houston at Miami | 11/23/1969 | HOA 21-15 |
| Denver at San Diego | 11/23/1969 | SDA 26-7 |
| Philadelphia at St. Louis | 11/23/1969 | SLN 28-17 |
| San Francisco at New Orleans | 11/23/1969 | SFN 24-20 |
| Buffalo at Boston | 11/23/1969 | BUA 31-28 |
| Cincinnati at New York AFL | 11/23/1969 | NYA 45-3 |
| San Diego at Houston | 11/27/1969 | SDA 34-7 |
| San Francisco at Dallas | 11/27/1969 | DAN 20-7 |
| Denver at Kansas City | 11/27/1969 | KCA 51-6 |
| Minnesota at Detroit | 11/27/1969 | MNN 34-17 |
| Boston at Miami | 11/30/1969 | BOA 20-13 |
| Oakland at New York AFL | 11/30/1969 | OAA 23-20 |
| Cincinnati at Buffalo | 11/30/1969 | BUA 29-9 |
| Los Angeles at Washington | 11/30/1969 | LAN 31-31 |
| Atlanta at Baltimore | 11/30/1969 | BAN 31-19 |
| Cleveland at Chicago | 11/30/1969 | CLN 24-14 |
| Pittsburgh at St. Louis | 11/30/1969 | SLN 34-24 |
| New York NFL at Green Bay | 11/30/1969 | GBN 21-17 |
| Philadelphia at New Orleans | 11/30/1969 | NON 24-7 |
| Chicago at San Francisco | 12/6/1969 | SFN 21-16 |
| New York AFL at Houston | 12/6/1969 | NYA 30-7 |
| Detroit at Baltimore | 12/7/1969 | DEN 17-13 |
| Green Bay at Cleveland | 12/7/1969 | CLN 35-14 |
| Minnesota at Los Angeles | 12/7/1969 | MNN 26-20 |
| New Orleans at Atlanta | 12/7/1969 | ATN 28-14 |
| Washington at Philadelphia | 12/7/1969 | WAN 37-35 |
| Cincinnati at Oakland | 12/7/1969 | OAA 39-21 |
| Denver at Miami | 12/7/1969 | MIA 24-3 |
| Buffalo at Kansas City | 12/7/1969 | KCA 17-9 |
| Dallas at Pittsburgh | 12/7/1969 | DAN 22-7 |
| Boston at San Diego | 12/7/1969 | SDA 31-28 |
| St. Louis at New York NFL | 12/7/1969 | NYN 30-17 |
| Baltimore at Dallas | 12/13/1969 | BAN 27-20 |
| Kansas City at Oakland | 12/13/1969 | KCA 32-20 |
| Green Bay at Chicago | 12/14/1969 | GBN 21-10 |
| Los Angeles at Detroit | 12/14/1969 | LAN 22-9 |
| New Orleans at Washington | 12/14/1969 | WAN 31-28 |
| Atlanta at Philadelphia | 12/14/1969 | ATN 38-28 |
| New York NFL at Pittsburgh | 12/14/1969 | PIN 21-16 |
| Cleveland at St. Louis | 12/14/1969 | CLN 35-24 |
| San Francisco at Minnesota | 12/14/1969 | SFN 17-6 |
| Buffalo at San Diego | 12/14/1969 | BUA 20-0 |
| Cincinnati at Denver | 12/14/1969 | DEA 28-17 |
| New York AFL at Miami | 12/14/1969 | NYA 34-12 |
| Boston at Houston | 12/14/1969 | HOA 20-16 |
| Detroit at Chicago | 12/21/1969 | DEN 13-10 |
| Cleveland at New York NFL | 12/21/1969 | NYN 28-17 |
| Baltimore at Los Angeles | 12/21/1969 | LAN 33-10 |
| Minnesota at Atlanta | 12/21/1969 | MNN 17-17 |
| Philadelphia at San Francisco | 12/21/1969 | SFN 35-28 |
| Pittsburgh at New Orleans | 12/21/1969 | PIN 10-7 |
| St. Louis at Green Bay | 12/21/1969 | GBN 24-17 |
| Washington at Dallas | 12/21/1969 | DAN 38-21 |