| Game Results |
| Teams | Date | Score |
| Los Angeles at Atlanta | 9/18/1977 | LAN 23-16 |
| Baltimore at Seattle | 9/18/1977 | BAA 20-13 |
| Detroit at Chicago | 9/18/1977 | CHN 20-14 |
| Cleveland at Cincinnati | 9/18/1977 | CIA 41-31 |
| Dallas at Minnesota | 9/18/1977 | DAN 23-7 |
| St. Louis at Denver | 9/18/1977 | DEA 20-17 |
| Green Bay at New Orleans | 9/18/1977 | NON 14-10 |
| New York AFC at Houston | 9/18/1977 | HOA 24-23 |
| Miami at Buffalo | 9/18/1977 | MIA 35-7 |
| Kansas City at New England | 9/18/1977 | NEA 29-13 |
| Washington at New York NFC | 9/18/1977 | WAN 13-6 |
| San Diego at Oakland | 9/18/1977 | OAA 28-22 |
| Tampa Bay at Philadelphia | 9/18/1977 | PHN 20-0 |
| San Francisco at Pittsburgh | 9/19/1977 | PIA 38-13 |
| Minnesota at Tampa Bay | 9/24/1977 | TBN 9-6 |
| Baltimore at New York AFC | 9/25/1977 | BAA 36-10 |
| Seattle at Cincinnati | 9/25/1977 | CIA 27-12 |
| New York NFC at Dallas | 9/25/1977 | DAN 14-0 |
| Buffalo at Denver | 9/25/1977 | DEA 30-3 |
| New Orleans at Detroit | 9/25/1977 | DEN 14-13 |
| Houston at Green Bay | 9/25/1977 | GBN 24-13 |
| Philadelphia at Los Angeles | 9/25/1977 | LAN 28-24 |
| Miami at San Francisco | 9/25/1977 | MIA 35-17 |
| Oakland at Pittsburgh | 9/25/1977 | OAA 42-10 |
| San Diego at Kansas City | 9/25/1977 | KCA 14-10 |
| Chicago at St. Louis | 9/25/1977 | CHN 30-16 |
| Atlanta at Washington | 9/25/1977 | WAN 20-13 |
| New England at Cleveland | 9/26/1977 | CLA 30-27 |
| New York NFC at Atlanta | 10/2/1977 | NYN 17-14 |
| Buffalo at Baltimore | 10/2/1977 | BAA 28-10 |
| Tampa Bay at Dallas | 10/2/1977 | DAN 13-0 |
| Denver at Seattle | 10/2/1977 | DEA 35-10 |
| Philadelphia at Detroit | 10/2/1977 | PHN 17-13 |
| San Francisco at Los Angeles | 10/2/1977 | LAN 41-7 |
| Houston at Miami | 10/2/1977 | MIA 31-26 |
| Green Bay at Minnesota | 10/2/1977 | MIN 21-10 |
| New Orleans at Chicago | 10/2/1977 | CHN 20-17 |
| New England at New York AFC | 10/2/1977 | NEA 14-9 |
| Pittsburgh at Cleveland | 10/2/1977 | PIA 26-17 |
| Cincinnati at San Diego | 10/2/1977 | SDA 31-14 |
| St. Louis at Washington | 10/2/1977 | WAN 38-35 |
| Oakland at Kansas City | 10/3/1977 | OAA 28-24 |
| Atlanta at San Francisco | 10/9/1977 | ATN 24-17 |
| Miami at Baltimore | 10/9/1977 | MIA 21-13 |
| Cincinnati at Green Bay | 10/9/1977 | GBN 31-13 |
| Dallas at St. Louis | 10/9/1977 | DAN 32-14 |
| Kansas City at Denver | 10/9/1977 | DEA 34-0 |
| Pittsburgh at Houston | 10/9/1977 | HOA 24-16 |
| Detroit at Minnesota | 10/9/1977 | MIN 23-7 |
| Seattle at New England | 10/9/1977 | NEA 28-21 |
| New York AFC at Buffalo | 10/9/1977 | BUA 24-20 |
| Oakland at Cleveland | 10/9/1977 | OAA 31-16 |
| Philadelphia at New York NFC | 10/9/1977 | NYN 10-9 |
| San Diego at New Orleans | 10/9/1977 | SDA 34-6 |
| Washington at Tampa Bay | 10/9/1977 | WAN 13-3 |
| Los Angeles at Chicago | 10/10/1977 | LAN 28-7 |
| Baltimore at Kansas City | 10/16/1977 | BAA 17-16 |
| Atlanta at Buffalo | 10/16/1977 | ATN 23-19 |
| Cleveland at Houston | 10/16/1977 | HOA 23-17 |
| Washington at Dallas | 10/16/1977 | WAN 19-13 |
| Denver at Oakland | 10/16/1977 | OAA 38-24 |
| Green Bay at Detroit | 10/16/1977 | DEN 28-7 |
| New Orleans at Los Angeles | 10/16/1977 | LAN 27-13 |
| New York AFC at Miami | 10/16/1977 | MIA 45-21 |
| Chicago at Minnesota | 10/16/1977 | MIN 17-14 |
| New England at San Diego | 10/16/1977 | SDA 10-3 |
| San Francisco at New York NFC | 10/16/1977 | NYN 31-17 |
| Tampa Bay at Seattle | 10/16/1977 | TBN 34-10 |
| St. Louis at Philadelphia | 10/16/1977 | PHN 24-21 |
| Cincinnati at Pittsburgh | 10/17/1977 | PIA 22-10 |
| Atlanta at Chicago | 10/23/1977 | CHN 31-10 |
| Cleveland at Buffalo | 10/23/1977 | BUA 22-17 |
| Dallas at Philadelphia | 10/23/1977 | DAN 24-7 |
| Denver at Cincinnati | 10/23/1977 | CIA 23-13 |
| Green Bay at Tampa Bay | 10/23/1977 | GBN 15-6 |
| Kansas City at San Diego | 10/23/1977 | KCA 24-21 |
| Seattle at Miami | 10/23/1977 | MIA 21-7 |
| Baltimore at New England | 10/23/1977 | BAA 41-28 |
| New York NFC at Washington | 10/23/1977 | WAN 6-3 |
| Oakland at New York AFC | 10/23/1977 | OAA 42-24 |
| Houston at Pittsburgh | 10/23/1977 | HOA 31-26 |
| Detroit at San Francisco | 10/23/1977 | DEN 20-14 |
| New Orleans at St. Louis | 10/23/1977 | SLN 21-14 |
| Minnesota at Los Angeles | 10/24/1977 | LAN 29-20 |
| Pittsburgh at Baltimore | 10/30/1977 | BAA 21-7 |
| Chicago at Green Bay | 10/30/1977 | GBN 22-3 |
| Houston at Cincinnati | 10/30/1977 | CIA 17-14 |
| Kansas City at Cleveland | 10/30/1977 | CLA 38-34 |
| Detroit at Dallas | 10/30/1977 | DAN 23-13 |
| Minnesota at Atlanta | 10/30/1977 | MIN 14-0 |
| New York AFC at New England | 10/30/1977 | NEA 34-0 |
| Los Angeles at New Orleans | 10/30/1977 | LAN 24-7 |
| Oakland at Denver | 10/30/1977 | DEA 27-23 |
| San Diego at Miami | 10/30/1977 | MIA 30-23 |
| Tampa Bay at San Francisco | 10/30/1977 | TBN 16-0 |
| Buffalo at Seattle | 10/30/1977 | SEA 31-28 |
| Philadelphia at Washington | 10/30/1977 | PHN 21-6 |
| New York NFC at St. Louis | 10/31/1977 | NYN 40-10 |
| Buffalo at New England | 11/6/1977 | NEA 12-10 |
| Cincinnati at Cleveland | 11/6/1977 | CLA 34-28 |
| Dallas at New York NFC | 11/6/1977 | DAN 16-0 |
| Pittsburgh at Denver | 11/6/1977 | PIA 17-10 |
| San Diego at Detroit | 11/6/1977 | SDA 31-10 |
| Chicago at Houston | 11/6/1977 | CHN 28-24 |
| Green Bay at Kansas City | 11/6/1977 | GBN 31-24 |
| Tampa Bay at Los Angeles | 11/6/1977 | LAN 31-14 |
| Miami at New York AFC | 11/6/1977 | MIA 26-0 |
| Seattle at Oakland | 11/6/1977 | OAA 41-10 |
| New Orleans at Philadelphia | 11/6/1977 | PHN 14-12 |
| San Francisco at Atlanta | 11/6/1977 | ATN 26-6 |
| St. Louis at Minnesota | 11/6/1977 | MIN 33-27 |
| Washington at Baltimore | 11/7/1977 | BAA 24-14 |
| Detroit at Atlanta | 11/13/1977 | DEN 17-14 |
| Baltimore at Buffalo | 11/13/1977 | BAA 34-3 |
| Kansas City at Chicago | 11/13/1977 | CHN 20-14 |
| Denver at San Diego | 11/13/1977 | SDA 22-10 |
| Los Angeles at Green Bay | 11/13/1977 | LAN 37-7 |
| New England at Miami | 11/13/1977 | NEA 27-27 |
| Cincinnati at Minnesota | 11/13/1977 | MIN 38-17 |
| New York NFC at Tampa Bay | 11/13/1977 | NYN 20-14 |
| Houston at Oakland | 11/13/1977 | HOA 16-10 |
| Cleveland at Pittsburgh | 11/13/1977 | CLA 23-20 |
| San Francisco at New Orleans | 11/13/1977 | SFN 28-20 |
| Seattle at New York AFC | 11/13/1977 | SEA 35-17 |
| Washington at Philadelphia | 11/13/1977 | PHN 17-14 |
| St. Louis at Dallas | 11/14/1977 | DAN 27-21 |
| New York AFC at Baltimore | 11/20/1977 | BAA 33-27 |
| Minnesota at Chicago | 11/20/1977 | MIN 34-21 |
| Miami at Cincinnati | 11/20/1977 | MIA 21-10 |
| Cleveland at New York NFC | 11/20/1977 | NYN 20-17 |
| Denver at Kansas City | 11/20/1977 | DEA 15-7 |
| Tampa Bay at Detroit | 11/20/1977 | TBN 13-7 |
| Houston at Seattle | 11/20/1977 | HOA 33-3 |
| Los Angeles at San Francisco | 11/20/1977 | LAN 24-0 |
| New England at Buffalo | 11/20/1977 | NEA 20-0 |
| Atlanta at New Orleans | 11/20/1977 | ATN 30-24 |
| Dallas at Pittsburgh | 11/20/1977 | DAN 30-17 |
| Oakland at San Diego | 11/20/1977 | SDA 34-12 |
| Philadelphia at St. Louis | 11/20/1977 | SLN 20-7 |
| Green Bay at Washington | 11/21/1977 | WAN 22-0 |
| Chicago at Detroit | 11/24/1977 | DEN 28-13 |
| Miami at St. Louis | 11/24/1977 | SLN 31-17 |
| Atlanta at Tampa Bay | 11/27/1977 | TBN 9-6 |
| New York NFC at Cincinnati | 11/27/1977 | NYN 24-17 |
| Dallas at Washington | 11/27/1977 | DAN 16-13 |
| Baltimore at Denver | 11/27/1977 | DEA 12-0 |
| Kansas City at Houston | 11/27/1977 | HOA 17-10 |
| Los Angeles at Cleveland | 11/27/1977 | LAN 24-21 |
| Minnesota at Green Bay | 11/27/1977 | MIN 19-13 |
| Philadelphia at New England | 11/27/1977 | PHN 12-6 |
| Pittsburgh at New York AFC | 11/27/1977 | PIA 31-14 |
| San Diego at Seattle | 11/27/1977 | SDA 26-13 |
| New Orleans at San Francisco | 11/27/1977 | NON 20-14 |
| Buffalo at Oakland | 11/28/1977 | OAA 43-0 |
| Chicago at Tampa Bay | 12/4/1977 | TBN 24-14 |
| Cincinnati at Kansas City | 12/4/1977 | CIA 14-7 |
| Philadelphia at Dallas | 12/4/1977 | DAN 22-10 |
| Denver at Houston | 12/4/1977 | DEA 27-21 |
| Detroit at Green Bay | 12/4/1977 | GBN 21-7 |
| Oakland at Los Angeles | 12/4/1977 | OAA 28-17 |
| San Francisco at Minnesota | 12/4/1977 | MIN 30-13 |
| New England at Atlanta | 12/4/1977 | NEA 7-3 |
| St. Louis at New York NFC | 12/4/1977 | NYN 27-14 |
| New York AFC at New Orleans | 12/4/1977 | NYA 9-3 |
| Seattle at Pittsburgh | 12/4/1977 | SEA 38-17 |
| Cleveland at San Diego | 12/4/1977 | SDA 28-20 |
| Washington at Buffalo | 12/4/1977 | WAN 28-3 |
| Baltimore at Miami | 12/5/1977 | BAA 27-23 |
| Pittsburgh at Cincinnati | 12/10/1977 | CIA 34-23 |
| Washington at St. Louis | 12/10/1977 | SLN 33-27 |
| Buffalo at New York AFC | 12/11/1977 | NYA 30-21 |
| Green Bay at Chicago | 12/11/1977 | GBN 23-22 |
| San Diego at Denver | 12/11/1977 | DEA 20-17 |
| Detroit at Baltimore | 12/11/1977 | DEN 7-6 |
| Houston at Cleveland | 12/11/1977 | HOA 20-3 |
| Atlanta at Los Angeles | 12/11/1977 | LAN 20-6 |
| Miami at New England | 12/11/1977 | MIA 28-7 |
| Minnesota at Oakland | 12/11/1977 | MIN 24-21 |
| New York NFC at Philadelphia | 12/11/1977 | PHN 6-3 |
| Seattle at Kansas City | 12/11/1977 | SEA 24-10 |
| Tampa Bay at New Orleans | 12/11/1977 | TBN 26-23 |
| Dallas at San Francisco | 12/12/1977 | DAN 27-17 |
| Buffalo at Miami | 12/17/1977 | MIA 27-14 |
| Minnesota at Detroit | 12/17/1977 | MIN 34-14 |
| Los Angeles at Washington | 12/17/1977 | LAN 28-24 |
| New Orleans at Atlanta | 12/18/1977 | ATN 27-17 |
| New England at Baltimore | 12/18/1977 | NEA 20-17 |
| Chicago at New York NFC | 12/18/1977 | CHN 24-7 |
| Denver at Dallas | 12/18/1977 | DAN 28-13 |
| San Francisco at Green Bay | 12/18/1977 | SFN 30-28 |
| Cincinnati at Houston | 12/18/1977 | HOA 28-17 |
| Kansas City at Oakland | 12/18/1977 | OAA 23-21 |
| New York AFC at Philadelphia | 12/18/1977 | PHN 33-13 |
| Pittsburgh at San Diego | 12/18/1977 | SDA 20-9 |
| Cleveland at Seattle | 12/18/1977 | CLA 31-10 |
| St. Louis at Tampa Bay | 12/18/1977 | TBN 17-16 |