| Game Results |
| Teams | Date | Score |
| New York NFC at Tampa Bay | 9/2/1978 | NYN 13-0 |
| Houston at Atlanta | 9/3/1978 | HOA 20-6 |
| St. Louis at Chicago | 9/3/1978 | CHN 35-14 |
| San Francisco at Cleveland | 9/3/1978 | CLA 33-14 |
| Oakland at Denver | 9/3/1978 | DEA 20-10 |
| Green Bay at Detroit | 9/3/1978 | DEN 17-7 |
| Kansas City at Cincinnati | 9/3/1978 | KCA 12-9 |
| Los Angeles at Philadelphia | 9/3/1978 | PHN 20-17 |
| Minnesota at New Orleans | 9/3/1978 | NON 16-7 |
| Miami at New York AFC | 9/3/1978 | NYA 23-20 |
| Pittsburgh at Buffalo | 9/3/1978 | PIA 41-6 |
| San Diego at Seattle | 9/3/1978 | SEA 31-30 |
| Washington at New England | 9/3/1978 | WAN 17-14 |
| Baltimore at Dallas | 9/4/1978 | BAA 27-23 |
| Detroit at Tampa Bay | 9/9/1978 | DEN 27-7 |
| Chicago at San Francisco | 9/10/1978 | CHN 23-0 |
| Cincinnati at Cleveland | 9/10/1978 | CNA 30-20 |
| Dallas at New York NFC | 9/10/1978 | NYN 33-27 |
| New Orleans at Green Bay | 9/10/1978 | NON 13-10 |
| Houston at Kansas City | 9/10/1978 | KCA 17-6 |
| Atlanta at Los Angeles | 9/10/1978 | LAN 21-17 |
| Miami at Baltimore | 9/10/1978 | MIA 24-10 |
| New England at St. Louis | 9/10/1978 | NEA 24-16 |
| New York AFC at Buffalo | 9/10/1978 | NYA 30-21 |
| Oakland at San Diego | 9/10/1978 | SDA 37-14 |
| Seattle at Pittsburgh | 9/10/1978 | SEA 41-34 |
| Philadelphia at Washington | 9/10/1978 | PHN 27-9 |
| Denver at Minnesota | 9/11/1978 | DEA 27-27 |
| Chicago at Detroit | 9/17/1978 | DEN 42-17 |
| Cleveland at Atlanta | 9/17/1978 | ATN 17-10 |
| San Diego at Denver | 9/17/1978 | SDA 16-7 |
| San Francisco at Houston | 9/17/1978 | HOA 29-7 |
| Dallas at Los Angeles | 9/17/1978 | DAN 34-23 |
| Buffalo at Miami | 9/17/1978 | MIA 34-3 |
| Kansas City at New York NFC | 9/17/1978 | NYN 17-6 |
| Oakland at Green Bay | 9/17/1978 | GBN 15-9 |
| Philadelphia at New Orleans | 9/17/1978 | PHN 13-6 |
| Pittsburgh at Cincinnati | 9/17/1978 | PIA 28-10 |
| Seattle at New York AFC | 9/17/1978 | NYA 28-20 |
| Tampa Bay at Minnesota | 9/17/1978 | MNN 21-13 |
| Washington at St. Louis | 9/17/1978 | SLN 10-7 |
| Baltimore at New England | 9/18/1978 | NEA 35-9 |
| Baltimore at Buffalo | 9/24/1978 | BAA 28-16 |
| St. Louis at Dallas | 9/24/1978 | DAN 23-17 |
| Denver at Kansas City | 9/24/1978 | DEA 27-6 |
| Green Bay at San Diego | 9/24/1978 | SDA 29-10 |
| Los Angeles at Houston | 9/24/1978 | LAN 28-17 |
| New England at Oakland | 9/24/1978 | OAA 20-7 |
| New Orleans at Cincinnati | 9/24/1978 | NON 24-7 |
| San Francisco at New York NFC | 9/24/1978 | SFN 17-6 |
| Miami at Philadelphia | 9/24/1978 | PHN 31-25 |
| Cleveland at Pittsburgh | 9/24/1978 | PIA 24-3 |
| Detroit at Seattle | 9/24/1978 | SEA 28-17 |
| Atlanta at Tampa Bay | 9/24/1978 | TBN 25-21 |
| New York AFC at Washington | 9/24/1978 | WAN 24-13 |
| Minnesota at Chicago | 9/25/1978 | MNN 10-6 |
| New York NFC at Atlanta | 10/1/1978 | NYN 16-10 |
| Kansas City at Buffalo | 10/1/1978 | KCA 41-10 |
| Seattle at Denver | 10/1/1978 | SEA 23-3 |
| Detroit at Green Bay | 10/1/1978 | GBN 31-23 |
| Houston at Cleveland | 10/1/1978 | CLA 14-10 |
| Los Angeles at New Orleans | 10/1/1978 | LAN 16-10 |
| St. Louis at Miami | 10/1/1978 | MIA 28-21 |
| Minnesota at Tampa Bay | 10/1/1978 | MNN 16-10 |
| San Diego at New England | 10/1/1978 | NEA 26-24 |
| Oakland at Chicago | 10/1/1978 | CHN 19-17 |
| Philadelphia at Baltimore | 10/1/1978 | PHN 34-6 |
| Pittsburgh at New York AFC | 10/1/1978 | NYA 19-17 |
| Cincinnati at San Francisco | 10/1/1978 | SFN 19-14 |
| Dallas at Washington | 10/2/1978 | WAN 17-10 |
| Baltimore at St. Louis | 10/8/1978 | BAA 38-31 |
| Cleveland at New Orleans | 10/8/1978 | NON 28-21 |
| New York NFC at Dallas | 10/8/1978 | NYN 23-21 |
| Chicago at Green Bay | 10/8/1978 | CHN 17-14 |
| San Francisco at Los Angeles | 10/8/1978 | SFN 20-3 |
| Philadelphia at New England | 10/8/1978 | PHN 24-21 |
| Buffalo at New York AFC | 10/8/1978 | NYA 41-10 |
| Houston at Oakland | 10/8/1978 | HOA 44-13 |
| Atlanta at Pittsburgh | 10/8/1978 | PIA 27-6 |
| Denver at San Diego | 10/8/1978 | DEA 21-20 |
| Minnesota at Seattle | 10/8/1978 | MNN 17-16 |
| Tampa Bay at Kansas City | 10/8/1978 | KCA 16-13 |
| Washington at Detroit | 10/8/1978 | DEN 16-14 |
| Cincinnati at Miami | 10/9/1978 | MIA 27-17 |
| Detroit at Atlanta | 10/15/1978 | ATN 31-7 |
| Dallas at St. Louis | 10/15/1978 | DAN 31-17 |
| Seattle at Green Bay | 10/15/1978 | SEA 27-10 |
| Buffalo at Houston | 10/15/1978 | HOA 20-17 |
| Los Angeles at Minnesota | 10/15/1978 | MNN 17-3 |
| Miami at San Diego | 10/15/1978 | SDA 19-10 |
| New England at Cincinnati | 10/15/1978 | NEA 14-3 |
| New Orleans at San Francisco | 10/15/1978 | NON 21-17 |
| Tampa Bay at New York NFC | 10/15/1978 | NYN 30-13 |
| New York AFC at Baltimore | 10/15/1978 | NYA 22-17 |
| Kansas City at Oakland | 10/15/1978 | OAA 13-12 |
| Washington at Philadelphia | 10/15/1978 | PHN 31-3 |
| Pittsburgh at Cleveland | 10/15/1978 | PIA 38-34 |
| Chicago at Denver | 10/16/1978 | DEA 27-24 |
| Atlanta at San Francisco | 10/22/1978 | ATN 35-21 |
| Denver at Baltimore | 10/22/1978 | DEA 13-10 |
| Cincinnati at Buffalo | 10/22/1978 | CNA 31-13 |
| Philadelphia at Dallas | 10/22/1978 | DAN 34-14 |
| San Diego at Detroit | 10/22/1978 | SDA 24-10 |
| Cleveland at Kansas City | 10/22/1978 | CLA 33-30 |
| Green Bay at Minnesota | 10/22/1978 | MNN 31-17 |
| Miami at New England | 10/22/1978 | NEA 24-20 |
| New Orleans at Los Angeles | 10/22/1978 | LAN 23-21 |
| Washington at New York NFC | 10/22/1978 | WAN 13-10 |
| St. Louis at New York AFC | 10/22/1978 | NYA 24-13 |
| Oakland at Seattle | 10/22/1978 | OAA 31-24 |
| Chicago at Tampa Bay | 10/22/1978 | TBN 23-10 |
| Houston at Pittsburgh | 10/23/1978 | PIA 44-7 |
| Minnesota at Dallas | 10/26/1978 | DAN 23-10 |
| Houston at Cincinnati | 10/29/1978 | HOA 16-9 |
| Buffalo at Cleveland | 10/29/1978 | CLA 24-17 |
| Denver at Seattle | 10/29/1978 | SEA 21-15 |
| Detroit at Chicago | 10/29/1978 | CHN 23-17 |
| Tampa Bay at Green Bay | 10/29/1978 | GBN 19-10 |
| Baltimore at Miami | 10/29/1978 | MIA 19-14 |
| New York AFC at New England | 10/29/1978 | NEA 31-17 |
| New York NFC at New Orleans | 10/29/1978 | NYN 21-7 |
| Kansas City at Pittsburgh | 10/29/1978 | PIA 30-24 |
| San Diego at Oakland | 10/29/1978 | SDA 37-17 |
| St. Louis at Philadelphia | 10/29/1978 | PHN 23-7 |
| San Francisco at Washington | 10/29/1978 | SFN 13-10 |
| Los Angeles at Atlanta | 10/30/1978 | ATN 38-28 |
| San Francisco at Atlanta | 11/5/1978 | ATN 29-9 |
| Cleveland at Houston | 11/5/1978 | HOA 17-10 |
| Tampa Bay at Los Angeles | 11/5/1978 | LAN 27-9 |
| Dallas at Miami | 11/5/1978 | DAN 27-20 |
| Detroit at Minnesota | 11/5/1978 | MNN 17-12 |
| New England at Buffalo | 11/5/1978 | NEA 20-14 |
| New York AFC at Denver | 11/5/1978 | DEA 27-14 |
| Oakland at Kansas City | 11/5/1978 | OAA 27-3 |
| Green Bay at Philadelphia | 11/5/1978 | PHN 21-10 |
| New Orleans at Pittsburgh | 11/5/1978 | PIA 27-21 |
| Cincinnati at San Diego | 11/5/1978 | CNA 13-8 |
| Seattle at Chicago | 11/5/1978 | SEA 20-17 |
| New York NFC at St. Louis | 11/5/1978 | NYN 28-3 |
| Washington at Baltimore | 11/6/1978 | WAN 15-6 |
| Atlanta at New Orleans | 11/12/1978 | ATN 13-10 |
| Baltimore at Seattle | 11/12/1978 | BAA 35-24 |
| Dallas at Green Bay | 11/12/1978 | DAN 31-20 |
| Denver at Cleveland | 11/12/1978 | CLA 24-7 |
| Tampa Bay at Detroit | 11/12/1978 | DEN 33-20 |
| Houston at New England | 11/12/1978 | HOA 24-13 |
| Pittsburgh at Los Angeles | 11/12/1978 | LAN 37-10 |
| Miami at Buffalo | 11/12/1978 | MIA 31-7 |
| Chicago at Minnesota | 11/12/1978 | CHN 16-10 |
| New York AFC at Philadelphia | 11/12/1978 | PHN 35-7 |
| Kansas City at San Diego | 11/12/1978 | SDA 20-17 |
| St. Louis at San Francisco | 11/12/1978 | SFN 31-20 |
| New York NFC at Washington | 11/12/1978 | NYN 20-17 |
| Oakland at Cincinnati | 11/13/1978 | OAA 21-17 |
| Atlanta at Chicago | 11/19/1978 | CHN 24-3 |
| Cleveland at Baltimore | 11/19/1978 | BAA 22-21 |
| New Orleans at Dallas | 11/19/1978 | DAN 9-3 |
| Green Bay at Denver | 11/19/1978 | DEA 22-13 |
| Los Angeles at San Francisco | 11/19/1978 | SFN 20-14 |
| New England at New York AFC | 11/19/1978 | NEA 10-6 |
| Detroit at Oakland | 11/19/1978 | DEN 38-7 |
| Philadelphia at New York NFC | 11/19/1978 | NYN 19-9 |
| Cincinnati at Pittsburgh | 11/19/1978 | PIA 21-13 |
| San Diego at Minnesota | 11/19/1978 | SDA 33-17 |
| Seattle at Kansas City | 11/19/1978 | SEA 14-0 |
| St. Louis at Washington | 11/19/1978 | SLN 14-13 |
| Buffalo at Tampa Bay | 11/19/1978 | BUA 24-23 |
| Miami at Houston | 11/20/1978 | MIA 20-10 |
| Washington at Dallas | 11/23/1978 | DAN 30-10 |
| Denver at Detroit | 11/23/1978 | DEA 13-10 |
| New Orleans at Atlanta | 11/26/1978 | NON 20-17 |
| New York NFC at Buffalo | 11/26/1978 | NYN 16-13 |
| Tampa Bay at Chicago | 11/26/1978 | CHN 19-17 |
| Los Angeles at Cleveland | 11/26/1978 | CLA 26-10 |
| Cincinnati at Houston | 11/26/1978 | HOA 12-7 |
| San Diego at Kansas City | 11/26/1978 | SDA 30-14 |
| Minnesota at Green Bay | 11/26/1978 | MNN 21-14 |
| New England at Baltimore | 11/26/1978 | NEA 35-10 |
| New York AFC at Miami | 11/26/1978 | MIA 26-7 |
| Philadelphia at St. Louis | 11/26/1978 | PHN 21-13 |
| Seattle at Oakland | 11/26/1978 | SEA 51-21 |
| Pittsburgh at San Francisco | 11/27/1978 | PIA 17-0 |
| Atlanta at Cincinnati | 12/3/1978 | ATN 16-0 |
| New England at Dallas | 12/3/1978 | NEA 23-21 |
| Denver at Oakland | 12/3/1978 | DEA 21-16 |
| Green Bay at Tampa Bay | 12/3/1978 | GBN 20-10 |
| Buffalo at Kansas City | 12/3/1978 | BUA 17-16 |
| Los Angeles at New York NFC | 12/3/1978 | LAN 22-16 |
| Miami at Washington | 12/3/1978 | MIA 16-10 |
| Philadelphia at Minnesota | 12/3/1978 | PHN 24-10 |
| San Francisco at New Orleans | 12/3/1978 | SFN 35-20 |
| Baltimore at New York AFC | 12/3/1978 | NYA 24-17 |
| Pittsburgh at Houston | 12/3/1978 | PIA 17-16 |
| Cleveland at Seattle | 12/3/1978 | SEA 42-7 |
| Detroit at St. Louis | 12/3/1978 | DEN 31-21 |
| Chicago at San Diego | 12/4/1978 | CHN 34-14 |
| Minnesota at Detroit | 12/9/1978 | DEN 17-13 |
| Baltimore at Pittsburgh | 12/9/1978 | PIA 28-13 |
| Washington at Atlanta | 12/10/1978 | ATN 27-24 |
| Green Bay at Chicago | 12/10/1978 | CHN 23-21 |
| New York AFC at Cleveland | 12/10/1978 | NYA 37-34 |
| Dallas at Philadelphia | 12/10/1978 | DAN 37-0 |
| Kansas City at Denver | 12/10/1978 | KCA 16-3 |
| Houston at New Orleans | 12/10/1978 | HOA 17-13 |
| Oakland at Miami | 12/10/1978 | MIA 29-14 |
| Buffalo at New England | 12/10/1978 | BUA 34-17 |
| St. Louis at New York NFC | 12/10/1978 | SLN 16-12 |
| Seattle at San Diego | 12/10/1978 | SEA 13-10 |
| Tampa Bay at San Francisco | 12/10/1978 | TBN 13-10 |
| Cincinnati at Los Angeles | 12/11/1978 | LAN 21-10 |
| Chicago at Washington | 12/16/1978 | WAN 33-14 |
| Pittsburgh at Denver | 12/16/1978 | PIA 17-0 |
| Buffalo at Baltimore | 12/17/1978 | BAA 30-10 |
| Cleveland at Cincinnati | 12/17/1978 | CNA 20-7 |
| Dallas at New York AFC | 12/17/1978 | DAN 27-14 |
| San Francisco at Detroit | 12/17/1978 | DEN 23-0 |
| Green Bay at Los Angeles | 12/17/1978 | LAN 24-17 |
| New Orleans at Tampa Bay | 12/17/1978 | NON 21-13 |
| Minnesota at Oakland | 12/17/1978 | MNN 24-14 |
| New York NFC at Philadelphia | 12/17/1978 | NYN 26-21 |
| San Diego at Houston | 12/17/1978 | SDA 31-24 |
| Kansas City at Seattle | 12/17/1978 | SEA 27-14 |
| Atlanta at St. Louis | 12/17/1978 | SLN 24-12 |
| New England at Miami | 12/18/1978 | NEA 20-14 |