| Game Results |
| Teams | Date | Score |
| Atlanta at New Orleans | 9/7/1986 | NON 26-3 |
| Cleveland at Chicago | 9/7/1986 | CLA 27-14 |
| Los Angeles AFC at Denver | 9/7/1986 | DEA 27-7 |
| Detroit at Minnesota | 9/7/1986 | DEN 29-21 |
| Houston at Green Bay | 9/7/1986 | HOA 31-24 |
| Cincinnati at Kansas City | 9/7/1986 | CNA 17-16 |
| Los Angeles NFC at St. Louis | 9/7/1986 | LAN 27-10 |
| Indianapolis at New England | 9/7/1986 | NEA 35-10 |
| New York AFC at Buffalo | 9/7/1986 | NYA 31-23 |
| Miami at San Diego | 9/7/1986 | SDA 35-17 |
| San Francisco at Tampa Bay | 9/7/1986 | SFN 35-15 |
| Pittsburgh at Seattle | 9/7/1986 | PIA 20-17 |
| Philadelphia at Washington | 9/7/1986 | WAN 24-7 |
| New York NFC at Dallas | 9/8/1986 | NYN 24-20 |
| New England at New York AFC | 9/11/1986 | NEA 41-10 |
| St. Louis at Atlanta | 9/14/1986 | ATN 26-23 |
| Philadelphia at Chicago | 9/14/1986 | CHN 12-10 |
| Buffalo at Cincinnati | 9/14/1986 | CNA 30-28 |
| Cleveland at Houston | 9/14/1986 | CLA 33-13 |
| Dallas at Detroit | 9/14/1986 | DAN 26-13 |
| San Francisco at Los Angeles NFC | 9/14/1986 | LAN 21-10 |
| Indianapolis at Miami | 9/14/1986 | MIA 41-24 |
| Minnesota at Tampa Bay | 9/14/1986 | MNN 21-16 |
| Green Bay at New Orleans | 9/14/1986 | NON 16-10 |
| San Diego at New York NFC | 9/14/1986 | NYN 17-13 |
| Kansas City at Seattle | 9/14/1986 | SEA 41-13 |
| Los Angeles AFC at Washington | 9/14/1986 | LAA 19-13 |
| Denver at Pittsburgh | 9/15/1986 | PIA 17-13 |
| Cincinnati at Cleveland | 9/18/1986 | CNA 24-16 |
| Atlanta at Dallas | 9/21/1986 | DAN 31-24 |
| St. Louis at Buffalo | 9/21/1986 | SLN 26-20 |
| Denver at Philadelphia | 9/21/1986 | DEA 24-22 |
| Houston at Kansas City | 9/21/1986 | KCA 13-8 |
| Los Angeles NFC at Indianapolis | 9/21/1986 | INA 20-17 |
| Pittsburgh at Minnesota | 9/21/1986 | MNN 17-14 |
| New York NFC at Los Angeles AFC | 9/21/1986 | NYN 27-17 |
| Miami at New York AFC | 9/21/1986 | MIA 33-27 |
| New Orleans at San Francisco | 9/21/1986 | NON 30-27 |
| Seattle at New England | 9/21/1986 | SEA 38-24 |
| Tampa Bay at Detroit | 9/21/1986 | DEN 34-10 |
| Washington at San Diego | 9/21/1986 | WAN 27-7 |
| Chicago at Green Bay | 9/22/1986 | CHN 27-7 |
| Atlanta at Tampa Bay | 9/28/1986 | ATN 21-16 |
| Chicago at Cincinnati | 9/28/1986 | CHN 24-3 |
| Detroit at Cleveland | 9/28/1986 | CLA 20-13 |
| New England at Denver | 9/28/1986 | NEA 43-21 |
| Kansas City at Buffalo | 9/28/1986 | KCA 13-0 |
| San Diego at Los Angeles AFC | 9/28/1986 | LAA 23-10 |
| Green Bay at Minnesota | 9/28/1986 | MNN 24-21 |
| New Orleans at New York NFC | 9/28/1986 | NYN 31-19 |
| New York AFC at Indianapolis | 9/28/1986 | INA 23-21 |
| Los Angeles NFC at Philadelphia | 9/28/1986 | LAN 17-13 |
| Pittsburgh at Houston | 9/28/1986 | PIA 26-14 |
| San Francisco at Miami | 9/28/1986 | MIA 24-17 |
| Seattle at Washington | 9/28/1986 | WAN 17-13 |
| Dallas at St. Louis | 9/29/1986 | DAN 24-14 |
| Minnesota at Chicago | 10/5/1986 | CHN 34-21 |
| Cincinnati at Green Bay | 10/5/1986 | GBN 20-17 |
| Cleveland at Pittsburgh | 10/5/1986 | CLA 31-16 |
| Dallas at Denver | 10/5/1986 | DEA 17-16 |
| Houston at Detroit | 10/5/1986 | DEN 30-24 |
| Los Angeles AFC at Kansas City | 10/5/1986 | KCA 13-10 |
| Tampa Bay at Los Angeles NFC | 10/5/1986 | LAN 40-17 |
| Miami at New England | 10/5/1986 | NEA 41-23 |
| New York NFC at St. Louis | 10/5/1986 | NYN 34-6 |
| Buffalo at New York AFC | 10/5/1986 | NYA 31-27 |
| Philadelphia at Atlanta | 10/5/1986 | ATN 28-21 |
| Indianapolis at San Francisco | 10/5/1986 | SFN 42-14 |
| Washington at New Orleans | 10/5/1986 | NON 37-7 |
| San Diego at Seattle | 10/6/1986 | SDA 28-24 |
| Los Angeles NFC at Atlanta | 10/12/1986 | LAN 17-10 |
| Chicago at Houston | 10/12/1986 | CHN 25-0 |
| Kansas City at Cleveland | 10/12/1986 | CLA 38-14 |
| Washington at Dallas | 10/12/1986 | DAN 20-19 |
| Denver at San Diego | 10/12/1986 | SDA 30-17 |
| Detroit at Green Bay | 10/12/1986 | DEN 15-14 |
| Seattle at Los Angeles AFC | 10/12/1986 | LAA 19-6 |
| Buffalo at Miami | 10/12/1986 | BFA 42-40 |
| Minnesota at San Francisco | 10/12/1986 | MNN 27-24 |
| New Orleans at Indianapolis | 10/12/1986 | NON 19-0 |
| Philadelphia at New York NFC | 10/12/1986 | NYN 41-7 |
| New York AFC at New England | 10/12/1986 | NEA 37-20 |
| St. Louis at Tampa Bay | 10/12/1986 | SLN 38-24 |
| Pittsburgh at Cincinnati | 10/13/1986 | PIA 27-0 |
| Indianapolis at Buffalo | 10/19/1986 | BFA 19-13 |
| Houston at Cincinnati | 10/19/1986 | HOA 24-14 |
| Dallas at Philadelphia | 10/19/1986 | PHN 23-14 |
| Green Bay at Cleveland | 10/19/1986 | CLA 31-21 |
| San Diego at Kansas City | 10/19/1986 | SDA 17-14 |
| Los Angeles AFC at Miami | 10/19/1986 | LAA 13-3 |
| Detroit at Los Angeles NFC | 10/19/1986 | DEN 24-20 |
| Chicago at Minnesota | 10/19/1986 | CHN 31-17 |
| New England at Pittsburgh | 10/19/1986 | PIA 20-7 |
| Tampa Bay at New Orleans | 10/19/1986 | TBN 24-16 |
| San Francisco at Atlanta | 10/19/1986 | SFN 24-17 |
| New York NFC at Seattle | 10/19/1986 | SEA 24-13 |
| St. Louis at Washington | 10/19/1986 | WAN 17-7 |
| Denver at New York AFC | 10/20/1986 | DEA 37-17 |
| Detroit at Chicago | 10/26/1986 | CHN 16-3 |
| Cleveland at Minnesota | 10/26/1986 | MNN 38-10 |
| St. Louis at Dallas | 10/26/1986 | SLN 20-7 |
| Seattle at Denver | 10/26/1986 | SEA 21-17 |
| Tampa Bay at Kansas City | 10/26/1986 | KCA 16-6 |
| Los Angeles AFC at Houston | 10/26/1986 | LAA 20-3 |
| Atlanta at Los Angeles NFC | 10/26/1986 | LAN 27-14 |
| Miami at Indianapolis | 10/26/1986 | MIA 34-28 |
| New England at Buffalo | 10/26/1986 | NEA 37-30 |
| New Orleans at New York AFC | 10/26/1986 | NYA 34-27 |
| San Diego at Philadelphia | 10/26/1986 | PHN 27-3 |
| Cincinnati at Pittsburgh | 10/26/1986 | CNA 26-20 |
| San Francisco at Green Bay | 10/26/1986 | SFN 38-7 |
| Washington at New York NFC | 10/27/1986 | NYN 23-21 |
| Cincinnati at Detroit | 11/2/1986 | DEN 30-24 |
| Cleveland at Indianapolis | 11/2/1986 | INA 30-24 |
| Denver at Los Angeles AFC | 11/2/1986 | DEA 27-17 |
| Kansas City at San Diego | 11/2/1986 | SDA 19-7 |
| Houston at Miami | 11/2/1986 | MIA 40-20 |
| Atlanta at New England | 11/2/1986 | NEA 23-16 |
| San Francisco at New Orleans | 11/2/1986 | SFN 24-17 |
| Dallas at New York NFC | 11/2/1986 | DAN 31-28 |
| New York AFC at Seattle | 11/2/1986 | SEA 42-3 |
| Green Bay at Pittsburgh | 11/2/1986 | PIA 24-7 |
| Philadelphia at St. Louis | 11/2/1986 | SLN 16-7 |
| Buffalo at Tampa Bay | 11/2/1986 | TBN 34-29 |
| Minnesota at Washington | 11/2/1986 | WAN 24-14 |
| Los Angeles NFC at Chicago | 11/3/1986 | CHN 10-3 |
| Pittsburgh at Buffalo | 11/9/1986 | PIA 20-17 |
| Chicago at Tampa Bay | 11/9/1986 | CHN 27-6 |
| Cincinnati at Houston | 11/9/1986 | CNA 20-10 |
| Seattle at Kansas City | 11/9/1986 | SEA 22-14 |
| Los Angeles AFC at Dallas | 11/9/1986 | DAN 21-14 |
| Minnesota at Detroit | 11/9/1986 | MNN 12-10 |
| New England at Indianapolis | 11/9/1986 | NEA 36-14 |
| Los Angeles NFC at New Orleans | 11/9/1986 | LAN 28-13 |
| New York NFC at Philadelphia | 11/9/1986 | NYN 20-0 |
| New York AFC at Atlanta | 11/9/1986 | NYA 31-14 |
| San Diego at Denver | 11/9/1986 | DEA 27-14 |
| St. Louis at San Francisco | 11/9/1986 | SLN 19-14 |
| Washington at Green Bay | 11/9/1986 | WAN 20-20 |
| Miami at Cleveland | 11/10/1986 | MIA 44-14 |
| Chicago at Atlanta | 11/16/1986 | CHN 12-3 |
| Seattle at Cincinnati | 11/16/1986 | SEA 38-6 |
| Dallas at San Diego | 11/16/1986 | DAN 24-13 |
| Kansas City at Denver | 11/16/1986 | DEA 20-3 |
| Detroit at Philadelphia | 11/16/1986 | PHN 28-0 |
| Tampa Bay at Green Bay | 11/16/1986 | TBN 34-14 |
| Cleveland at Los Angeles AFC | 11/16/1986 | CLA 31-13 |
| Miami at Buffalo | 11/16/1986 | MIA 28-17 |
| New England at Los Angeles NFC | 11/16/1986 | LAN 27-20 |
| New Orleans at St. Louis | 11/16/1986 | NON 20-6 |
| New York NFC at Minnesota | 11/16/1986 | NYN 27-14 |
| Indianapolis at New York AFC | 11/16/1986 | NYA 21-10 |
| Houston at Pittsburgh | 11/16/1986 | PIA 27-16 |
| San Francisco at Washington | 11/17/1986 | WAN 26-6 |
| Los Angeles AFC at San Diego | 11/20/1986 | SDA 31-10 |
| Green Bay at Chicago | 11/23/1986 | GBN 13-0 |
| Minnesota at Cincinnati | 11/23/1986 | MNN 34-24 |
| Pittsburgh at Cleveland | 11/23/1986 | CLA 31-17 |
| Detroit at Tampa Bay | 11/23/1986 | DEN 41-31 |
| Indianapolis at Houston | 11/23/1986 | INA 27-7 |
| New Orleans at Los Angeles NFC | 11/23/1986 | NON 27-6 |
| Buffalo at New England | 11/23/1986 | BFA 24-20 |
| Denver at New York NFC | 11/23/1986 | NYN 27-10 |
| Kansas City at St. Louis | 11/23/1986 | KCA 27-21 |
| Atlanta at San Francisco | 11/23/1986 | SFN 31-13 |
| Philadelphia at Seattle | 11/23/1986 | SEA 27-10 |
| Dallas at Washington | 11/23/1986 | WAN 17-3 |
| New York AFC at Miami | 11/24/1986 | NYA 21-17 |
| Green Bay at Detroit | 11/27/1986 | DEN 28-21 |
| Seattle at Dallas | 11/27/1986 | SEA 27-3 |
| Atlanta at Miami | 11/30/1986 | ATN 17-14 |
| Buffalo at Kansas City | 11/30/1986 | KCA 16-10 |
| Pittsburgh at Chicago | 11/30/1986 | PIA 21-13 |
| Houston at Cleveland | 11/30/1986 | CLA 17-3 |
| Cincinnati at Denver | 11/30/1986 | DEA 37-13 |
| Los Angeles NFC at New York AFC | 11/30/1986 | LAN 31-20 |
| Tampa Bay at Minnesota | 11/30/1986 | MNN 31-23 |
| New England at New Orleans | 11/30/1986 | NON 30-17 |
| Philadelphia at Los Angeles AFC | 11/30/1986 | PHN 27-13 |
| San Diego at Indianapolis | 11/30/1986 | INA 17-14 |
| Washington at St. Louis | 11/30/1986 | WAN 25-20 |
| New York NFC at San Francisco | 12/1/1986 | NYN 17-7 |
| Tampa Bay at Chicago | 12/7/1986 | CHN 32-17 |
| Cincinnati at New England | 12/7/1986 | NEA 16-10 |
| Cleveland at Buffalo | 12/7/1986 | CLA 17-10 |
| Indianapolis at Atlanta | 12/7/1986 | ATN 28-10 |
| Denver at Kansas City | 12/7/1986 | DEA 19-3 |
| Dallas at Los Angeles NFC | 12/7/1986 | LAN 20-7 |
| Miami at New Orleans | 12/7/1986 | MIA 30-27 |
| Minnesota at Green Bay | 12/7/1986 | MNN 24-10 |
| New York NFC at Washington | 12/7/1986 | NYN 27-14 |
| Detroit at Pittsburgh | 12/7/1986 | PIA 35-31 |
| St. Louis at Philadelphia | 12/7/1986 | PHN 24-0 |
| Houston at San Diego | 12/7/1986 | SDA 24-3 |
| New York AFC at San Francisco | 12/7/1986 | NYA 27-20 |
| Los Angeles AFC at Seattle | 12/8/1986 | SEA 24-20 |
| Washington at Denver | 12/13/1986 | WAN 17-14 |
| Pittsburgh at New York AFC | 12/13/1986 | PIA 26-21 |
| Cleveland at Cincinnati | 12/14/1986 | CLA 28-17 |
| Green Bay at Tampa Bay | 12/14/1986 | TBN 23-3 |
| Minnesota at Houston | 12/14/1986 | HOA 20-14 |
| Buffalo at Indianapolis | 12/14/1986 | BFA 28-10 |
| Kansas City at Los Angeles AFC | 12/14/1986 | LAA 24-14 |
| Miami at Los Angeles NFC | 12/14/1986 | MIA 27-21 |
| New Orleans at Atlanta | 12/14/1986 | ATN 14-11 |
| St. Louis at New York NFC | 12/14/1986 | NYN 14-7 |
| Philadelphia at Dallas | 12/14/1986 | DAN 27-6 |
| San Francisco at New England | 12/14/1986 | NEA 48-7 |
| Seattle at San Diego | 12/14/1986 | SEA 36-7 |
| Chicago at Detroit | 12/15/1986 | CHN 27-0 |
| Los Angeles NFC at San Francisco | 12/19/1986 | SFN 24-20 |
| Green Bay at New York NFC | 12/20/1986 | NYN 30-13 |
| Denver at Seattle | 12/20/1986 | SEA 37-10 |
| Atlanta at Detroit | 12/21/1986 | DEN 24-6 |
| Chicago at Dallas | 12/21/1986 | CHN 13-7 |
| New York AFC at Cincinnati | 12/21/1986 | CNA 21-7 |
| San Diego at Cleveland | 12/21/1986 | SDA 17-7 |
| Buffalo at Houston | 12/21/1986 | BFA 24-10 |
| Indianapolis at Los Angeles AFC | 12/21/1986 | LAA 38-24 |
| Kansas City at Pittsburgh | 12/21/1986 | PIA 23-20 |
| New Orleans at Minnesota | 12/21/1986 | MNN 35-16 |
| Tampa Bay at St. Louis | 12/21/1986 | SLN 23-7 |
| Washington at Philadelphia | 12/21/1986 | WAN 18-7 |
| New England at Miami | 12/22/1986 | NEA 48-21 |