| Game Results |
| Teams | Date | Score |
| Atlanta at Detroit | 9/4/1988 | DEN 20-17 |
| Cleveland at Kansas City | 9/4/1988 | CLA 17-6 |
| Dallas at Pittsburgh | 9/4/1988 | DAN 37-31 |
| Houston at Indianapolis | 9/4/1988 | HOA 24-20 |
| Miami at Chicago | 9/4/1988 | CHN 30-27 |
| Minnesota at Buffalo | 9/4/1988 | BUA 17-10 |
| New York AFC at New England | 9/4/1988 | NEA 31-30 |
| Philadelphia at Tampa Bay | 9/4/1988 | PHN 34-3 |
| Phoenix at Cincinnati | 9/4/1988 | CNA 24-21 |
| Los Angeles NFC at Green Bay | 9/4/1988 | GBN 38-30 |
| San Diego at Los Angeles AFC | 9/4/1988 | SDA 37-28 |
| San Francisco at New Orleans | 9/4/1988 | NON 41-17 |
| Seattle at Denver | 9/4/1988 | SEA 17-3 |
| Washington at New York NFC | 9/5/1988 | NYN 41-26 |
| Chicago at Indianapolis | 9/11/1988 | INA 23-17 |
| Cincinnati at Philadelphia | 9/11/1988 | PHN 31-28 |
| Detroit at Los Angeles NFC | 9/11/1988 | LAN 28-3 |
| Kansas City at Seattle | 9/11/1988 | SEA 31-10 |
| Miami at Buffalo | 9/11/1988 | BUA 23-3 |
| New England at Minnesota | 9/11/1988 | MNN 31-14 |
| New Orleans at Atlanta | 9/11/1988 | NON 31-24 |
| New York AFC at Cleveland | 9/11/1988 | CLA 24-23 |
| Pittsburgh at Washington | 9/11/1988 | WAN 27-24 |
| Los Angeles AFC at Houston | 9/11/1988 | HOA 20-3 |
| San Diego at Denver | 9/11/1988 | DEA 27-17 |
| San Francisco at New York NFC | 9/11/1988 | NYN 31-13 |
| Tampa Bay at Green Bay | 9/11/1988 | TBN 31-6 |
| Dallas at Phoenix | 9/12/1988 | DAN 28-13 |
| Atlanta at San Francisco | 9/18/1988 | SFN 28-21 |
| Buffalo at New England | 9/18/1988 | BUA 31-17 |
| Cincinnati at Pittsburgh | 9/18/1988 | CNA 42-22 |
| Denver at Kansas City | 9/18/1988 | DEA 28-19 |
| Green Bay at Miami | 9/18/1988 | GBN 34-28 |
| Houston at New York AFC | 9/18/1988 | HOA 23-13 |
| Minnesota at Chicago | 9/18/1988 | CHN 26-20 |
| New Orleans at Detroit | 9/18/1988 | NON 10-7 |
| New York NFC at Dallas | 9/18/1988 | DAN 35-24 |
| Philadelphia at Washington | 9/18/1988 | WAN 34-17 |
| Phoenix at Tampa Bay | 9/18/1988 | PXN 26-6 |
| Los Angeles NFC at Los Angeles AFC | 9/18/1988 | LAN 31-9 |
| Seattle at San Diego | 9/18/1988 | SEA 21-10 |
| Indianapolis at Cleveland | 9/19/1988 | CLA 20-14 |
| Atlanta at Dallas | 9/25/1988 | ATN 20-14 |
| Chicago at Green Bay | 9/25/1988 | GBN 6-5 |
| Cleveland at Cincinnati | 9/25/1988 | CLA 23-21 |
| Miami at Indianapolis | 9/25/1988 | INA 33-10 |
| New England at Houston | 9/25/1988 | NEA 35-3 |
| New York AFC at Detroit | 9/25/1988 | NYA 37-7 |
| Philadelphia at Minnesota | 9/25/1988 | MNN 41-0 |
| Pittsburgh at Buffalo | 9/25/1988 | BUA 38-17 |
| Los Angeles AFC at Denver | 9/25/1988 | DEA 13-10 |
| Los Angeles NFC at New York NFC | 9/25/1988 | LAN 34-14 |
| San Diego at Kansas City | 9/25/1988 | SDA 31-10 |
| San Francisco at Seattle | 9/25/1988 | SEA 24-23 |
| Tampa Bay at New Orleans | 9/25/1988 | NON 45-6 |
| Washington at Phoenix | 9/25/1988 | PXN 10-9 |
| Buffalo at Chicago | 10/2/1988 | BUA 20-14 |
| Cincinnati at Los Angeles AFC | 10/2/1988 | CNA 24-17 |
| Cleveland at Pittsburgh | 10/2/1988 | PIA 38-14 |
| Denver at San Diego | 10/2/1988 | SDA 21-10 |
| Detroit at San Francisco | 10/2/1988 | SFN 21-16 |
| Green Bay at Tampa Bay | 10/2/1988 | TBN 27-13 |
| Houston at Philadelphia | 10/2/1988 | HOA 37-17 |
| Indianapolis at New England | 10/2/1988 | INA 27-26 |
| Kansas City at New York AFC | 10/2/1988 | KCA 36-27 |
| Minnesota at Miami | 10/2/1988 | MIA 24-14 |
| New York NFC at Washington | 10/2/1988 | NYN 27-16 |
| Phoenix at Los Angeles NFC | 10/2/1988 | LAN 23-17 |
| Seattle at Atlanta | 10/2/1988 | SEA 28-10 |
| Dallas at New Orleans | 10/3/1988 | NON 27-0 |
| Chicago at Detroit | 10/9/1988 | DEN 31-23 |
| Denver at San Francisco | 10/9/1988 | SFN 42-27 |
| Indianapolis at Buffalo | 10/9/1988 | BUA 24-17 |
| Kansas City at Houston | 10/9/1988 | KCA 38-27 |
| Miami at Los Angeles AFC | 10/9/1988 | MIA 38-31 |
| New England at Green Bay | 10/9/1988 | NEA 10-6 |
| New Orleans at San Diego | 10/9/1988 | NON 30-13 |
| New York AFC at Cincinnati | 10/9/1988 | NYA 41-21 |
| Pittsburgh at Phoenix | 10/9/1988 | PIA 28-23 |
| Los Angeles NFC at Atlanta | 10/9/1988 | LAN 31-7 |
| Seattle at Cleveland | 10/9/1988 | CLA 10-6 |
| Tampa Bay at Minnesota | 10/9/1988 | MNN 24-10 |
| Washington at Dallas | 10/9/1988 | DAN 27-21 |
| New York NFC at Philadelphia | 10/10/1988 | NYN 28-21 |
| Atlanta at Denver | 10/16/1988 | DEA 40-10 |
| Cincinnati at New England | 10/16/1988 | CNA 31-13 |
| Dallas at Chicago | 10/16/1988 | CHN 24-16 |
| Detroit at New York NFC | 10/16/1988 | DEN 12-3 |
| Green Bay at Minnesota | 10/16/1988 | MNN 10-0 |
| Houston at Pittsburgh | 10/16/1988 | HOA 23-10 |
| New Orleans at Seattle | 10/16/1988 | SEA 24-12 |
| Philadelphia at Cleveland | 10/16/1988 | CLA 31-6 |
| Phoenix at Washington | 10/16/1988 | WAN 27-24 |
| Los Angeles AFC at Kansas City | 10/16/1988 | LAA 21-20 |
| San Diego at Miami | 10/16/1988 | SDA 20-7 |
| San Francisco at Los Angeles NFC | 10/16/1988 | LAN 45-10 |
| Tampa Bay at Indianapolis | 10/16/1988 | TBN 30-14 |
| Buffalo at New York AFC | 10/17/1988 | NYA 33-14 |
| Cleveland at Phoenix | 10/23/1988 | PXN 27-17 |
| Dallas at Philadelphia | 10/23/1988 | PHN 27-14 |
| Denver at Pittsburgh | 10/23/1988 | PIA 26-21 |
| Detroit at Kansas City | 10/23/1988 | DEN 23-13 |
| Houston at Cincinnati | 10/23/1988 | HOA 34-17 |
| Indianapolis at San Diego | 10/23/1988 | SDA 20-10 |
| Minnesota at Tampa Bay | 10/23/1988 | MNN 27-3 |
| New England at Buffalo | 10/23/1988 | BUA 23-20 |
| New York NFC at Atlanta | 10/23/1988 | NYN 27-23 |
| New York AFC at Miami | 10/23/1988 | NYA 42-14 |
| Los Angeles AFC at New Orleans | 10/23/1988 | NON 42-30 |
| Seattle at Los Angeles NFC | 10/23/1988 | LAN 38-14 |
| Washington at Green Bay | 10/23/1988 | GBN 41-28 |
| San Francisco at Chicago | 10/24/1988 | SFN 27-7 |
| Atlanta at Philadelphia | 10/30/1988 | ATN 14-13 |
| Chicago at New England | 10/30/1988 | NEA 23-3 |
| Cincinnati at Cleveland | 10/30/1988 | CNA 27-14 |
| Green Bay at Buffalo | 10/30/1988 | BUA 31-3 |
| Kansas City at Los Angeles AFC | 10/30/1988 | LAA 23-21 |
| Miami at Tampa Bay | 10/30/1988 | TBN 29-19 |
| Minnesota at San Francisco | 10/30/1988 | SFN 30-20 |
| New York NFC at Detroit | 10/30/1988 | NYN 7-3 |
| Phoenix at Dallas | 10/30/1988 | PXN 33-24 |
| Pittsburgh at New York AFC | 10/30/1988 | NYA 34-20 |
| Los Angeles NFC at New Orleans | 10/30/1988 | LAN 31-17 |
| San Diego at Seattle | 10/30/1988 | SEA 14-13 |
| Washington at Houston | 10/30/1988 | HOA 27-24 |
| Denver at Indianapolis | 10/31/1988 | INA 28-7 |
| Buffalo at Seattle | 11/6/1988 | BUA 28-17 |
| Dallas at New York NFC | 11/6/1988 | DAN 14-9 |
| Detroit at Minnesota | 11/6/1988 | DEN 24-14 |
| Green Bay at Atlanta | 11/6/1988 | GBN 17-16 |
| Kansas City at Denver | 11/6/1988 | DEA 41-27 |
| Miami at New England | 11/6/1988 | NEA 30-24 |
| New Orleans at Washington | 11/6/1988 | WAN 31-28 |
| New York AFC at Indianapolis | 11/6/1988 | INA 34-31 |
| Pittsburgh at Cincinnati | 11/6/1988 | CNA 27-10 |
| Los Angeles NFC at Philadelphia | 11/6/1988 | LAN 39-24 |
| San Francisco at Phoenix | 11/6/1988 | SFN 17-16 |
| Tampa Bay at Chicago | 11/6/1988 | TBN 20-10 |
| Los Angeles AFC at San Diego | 11/6/1988 | SDA 36-7 |
| Cleveland at Houston | 11/7/1988 | CLA 26-3 |
| Chicago at Washington | 11/13/1988 | WAN 35-30 |
| Cincinnati at Kansas City | 11/13/1988 | KCA 33-14 |
| Cleveland at Denver | 11/13/1988 | CLA 21-6 |
| Houston at Seattle | 11/13/1988 | HOA 16-10 |
| Indianapolis at Green Bay | 11/13/1988 | INA 16-7 |
| New England at New York AFC | 11/13/1988 | NEA 23-13 |
| New Orleans at Los Angeles NFC | 11/13/1988 | NON 30-13 |
| New York NFC at Phoenix | 11/13/1988 | NYN 24-20 |
| Philadelphia at Pittsburgh | 11/13/1988 | PIA 20-17 |
| Los Angeles AFC at San Francisco | 11/13/1988 | SFN 10-0 |
| San Diego at Atlanta | 11/13/1988 | ATN 23-21 |
| Tampa Bay at Detroit | 11/13/1988 | DEN 23-13 |
| Minnesota at Dallas | 11/13/1988 | DAN 28-20 |
| Buffalo at Miami | 11/14/1988 | BUA 31-14 |
| Atlanta at Los Angeles AFC | 11/20/1988 | ATN 19-13 |
| Chicago at Tampa Bay | 11/20/1988 | CHN 21-17 |
| Cincinnati at Dallas | 11/20/1988 | CNA 35-31 |
| Denver at New Orleans | 11/20/1988 | NON 28-13 |
| Detroit at Green Bay | 11/20/1988 | GBN 9-7 |
| Indianapolis at Minnesota | 11/20/1988 | INA 17-0 |
| New York AFC at Buffalo | 11/20/1988 | BUA 30-27 |
| Philadelphia at New York NFC | 11/20/1988 | NYN 21-16 |
| Phoenix at Houston | 11/20/1988 | PXN 20-7 |
| Pittsburgh at Cleveland | 11/20/1988 | CLA 27-24 |
| San Diego at Los Angeles NFC | 11/20/1988 | SDA 34-26 |
| Seattle at Kansas City | 11/20/1988 | SEA 38-31 |
| New England at Miami | 11/20/1988 | NEA 35-3 |
| Washington at San Francisco | 11/21/1988 | WAN 33-28 |
| Houston at Dallas | 11/24/1988 | HOA 33-7 |
| Minnesota at Detroit | 11/24/1988 | DEN 17-13 |
| Buffalo at Cincinnati | 11/27/1988 | BUA 27-14 |
| Cleveland at Washington | 11/27/1988 | CLA 17-10 |
| Green Bay at Chicago | 11/27/1988 | CHN 24-9 |
| Kansas City at Pittsburgh | 11/27/1988 | KCA 32-7 |
| Miami at New York AFC | 11/27/1988 | NYA 37-7 |
| New England at Indianapolis | 11/27/1988 | NEA 41-27 |
| Phoenix at Philadelphia | 11/27/1988 | PHN 27-21 |
| Los Angeles NFC at Denver | 11/27/1988 | LAN 40-20 |
| San Francisco at San Diego | 11/27/1988 | SDA 29-14 |
| Tampa Bay at Atlanta | 11/27/1988 | TBN 38-24 |
| New York NFC at New Orleans | 11/27/1988 | NON 35-24 |
| Los Angeles AFC at Seattle | 11/28/1988 | SEA 27-13 |
| Buffalo at Tampa Bay | 12/4/1988 | BUA 35-30 |
| Dallas at Cleveland | 12/4/1988 | CLA 36-27 |
| Denver at Los Angeles AFC | 12/4/1988 | LAA 31-20 |
| Green Bay at Detroit | 12/4/1988 | DEN 15-9 |
| Indianapolis at Miami | 12/4/1988 | INA 40-31 |
| New Orleans at Minnesota | 12/4/1988 | MNN 20-17 |
| New York AFC at Kansas City | 12/4/1988 | NYA 27-26 |
| Phoenix at New York NFC | 12/4/1988 | PXN 37-17 |
| San Diego at Cincinnati | 12/4/1988 | CNA 31-14 |
| San Francisco at Atlanta | 12/4/1988 | SFN 31-26 |
| Seattle at New England | 12/4/1988 | SEA 17-13 |
| Washington at Philadelphia | 12/4/1988 | WAN 41-38 |
| Pittsburgh at Houston | 12/4/1988 | PIA 33-23 |
| Chicago at Los Angeles NFC | 12/5/1988 | LAN 17-13 |
| Indianapolis at New York AFC | 12/10/1988 | INA 50-38 |
| Philadelphia at Phoenix | 12/10/1988 | PXN 41-27 |
| Atlanta at Los Angeles NFC | 12/11/1988 | ATN 13-10 |
| Cincinnati at Houston | 12/11/1988 | CNA 40-21 |
| Dallas at Washington | 12/11/1988 | WAN 35-17 |
| Detroit at Chicago | 12/11/1988 | CHN 16-9 |
| Kansas City at New York NFC | 12/11/1988 | KCA 23-17 |
| Minnesota at Green Bay | 12/11/1988 | MNN 27-3 |
| New Orleans at San Francisco | 12/11/1988 | SFN 27-24 |
| Pittsburgh at San Diego | 12/11/1988 | PIA 17-14 |
| Los Angeles AFC at Buffalo | 12/11/1988 | LAA 23-23 |
| Tampa Bay at New England | 12/11/1988 | NEA 17-14 |
| Denver at Seattle | 12/11/1988 | SEA 27-10 |
| Cleveland at Miami | 12/12/1988 | MIA 27-21 |
| New England at Denver | 12/17/1988 | NEA 16-13 |
| Washington at Cincinnati | 12/17/1988 | WAN 34-24 |
| Atlanta at New Orleans | 12/18/1988 | NON 17-7 |
| Buffalo at Indianapolis | 12/18/1988 | BUA 20-19 |
| Detroit at Tampa Bay | 12/18/1988 | TBN 14-9 |
| Green Bay at Phoenix | 12/18/1988 | PXN 22-3 |
| Houston at Cleveland | 12/18/1988 | HOA 25-24 |
| Kansas City at San Diego | 12/18/1988 | SDA 22-21 |
| Miami at Pittsburgh | 12/18/1988 | PIA 77-10 |
| New York NFC at New York AFC | 12/18/1988 | NYA 20-17 |
| Philadelphia at Dallas | 12/18/1988 | PHN 27-7 |
| Seattle at Los Angeles AFC | 12/18/1988 | SEA 31-14 |
| Los Angeles NFC at San Francisco | 12/18/1988 | LAN 35-14 |
| Chicago at Minnesota | 12/19/1988 | CHN 14-13 |